Dr WONG Chak Lui, Carmen - carmencl@pathology.hku.hk
PhD HK

Education

Postdoctoral Training: Johns Hopkins University, USA

Doctor of Philosophy: The University of Hong Kong, Hong Kong

Master of Science: Hong Kong University of Science and Technology, Hong Kong

Bachelor of Science: The University of British Columbia, Canada

Awards and Honors

Presentation Award
The 3rd Annual Postdoc Symposium
Johns Hopkins Postdoctoral Association, Johns Hopkins University, 2011

Li Ka Shing Prize
(for the best PhD thesis in Faculty of Dentistry, Engineering, Medicine, and Science)
Graduate School, The University of Hong Kong, 2008-2009

Dr. KP Stephen Chang Gold Medal
(for the best PhD thesis in Faculty of Medicine)
Faculty of Medicine, The University of Hong Kong, 2008-2009

Hong Kong Young Scientist Award (Life Science)
Hong Kong Institution of Science, 2009

Croucher Foundation Fellowship
(for overseas postdoctoral fellow training)
Croucher Foundation, 2009-2011

Best Presentation Award
The 13th Postgraduate Symposium
Faculty of Medicine, The University of Hong Kong, 2008

Young Investigator Award
Hong Kong Shanghai International Liver Congress, 2008

Mary Sun Postgraduate Medical Scholarship
The University of Hong Kong, 2007-2008

Wong Ching Yee Postgraduate Medical Scholarship
The University of Hong Kong, 2007-2008

Swire Scholarship
The University of Hong Kong, 2007-2008

Young Investigator Award
The 14th Hong Kong International Cancer Congress, 2007

Recent Publications

Wong CC, Gilkes DG, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL. HIF-1 is an important regulator of metastatic niche formation. Proceedings of National Academy of Sciences. In press.

Zhang H, Wong CC, H Wei, Gilkes DG, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary, Winnard Jr P, Raman V, Zhen L, Mitzner W, Sukumar S, Semenza GL. HIF-1 dependent expression of angiopoietin-like 4 and LICAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene. In press.

Gao P, Wong CC, Lee JM, Tung EK, Wong CM, Ng IO. Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis. Journal of Hepatology. 2011 Jun;54(6):1177-84

Wong CM, Wong CC, Ng YL, Au SL, Ko FC, Ng IO. Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery. PLoS ONE.  2011 Feb 8;6(2):e16702.

Wong CC*, Wong CM*, Tung EK, Au SL, Lee JM, Man K, Ng IO.  MiR-139 suppresses metastasis and progression of hepatocellular carcinoma through regulation of Rho-kinase 2 (ROCK2). Gastroenterology. 2011 Jan;140(1):322-31. * contributed equally.

Wong CC, Wong CM, Au SL, Ng IO. Rho GTPases and Rho Effectors in Hepatocellular Carcinoma Metastasis: ROCK N’ Rho Move it. Liver International. 2010 May;30(5):642-56.

Wong CC, Wong CM, Tung EK, Man K, Ng IO.  Rho-kinase 2 (ROCK2) is frequently over-expressed in hepatocellular carcinoma and involved in tumor invasion.  Hepatology.  2009 May; 29 (5) 1583-94.

Wong CC, Wong CM, Ko FC, Chan LK, Ching YP, Yam JW, Ng IO.  Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma.  PLoS ONE.  2008 July 23; 3(7): e2779.

Wong CC, Ng IO. Gene expression in different stages of hepatocarcinogenesis. Journal of Gastroenterology and Hepatology. 2008 Jan; 23 (1): 1-3.

Lung HL, Lo CC, Wong CC, Cheung AK, Cheong KF, Wong N, Kwong FM, Chan KC, Law EW, Tsao SW, Chua D, Sham JS, Cheng Y, Stanbridge EJ, Robertson GP, Lung ML. Identification of tumor suppressive activity by irradiation microcell-mediated chromosome transfer and involvement of alpha B-crystallin in nasopharyngeal carcinoma. International Journal of Cancer. 2008 Mar; 122 (6): 1288-96.

Wong CM, Ng YL, Lee JM, Wong CC, Cheung OF, Chan CY, Tung EK, Ching YP, Ng IO. Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma. Hepatology. 2007 May; 45 (5): 1129-38.