LAM Ching Wan (Chemical Pathology)
ching-wanlam@pathology.hku.hk
MBChB; PhD; MAACB; FRCP(Glasg); FRCPA, FAACB; FHKCPath; FHKAM (Pathology)
Specialist in Pathology, Hong Kong Medical Council
Diplomate of the American Board of Toxicology (DABT)
Clinical, Educational, and Professional Service
- Director (Chemical Pathology), University Pathology Laboratory (UPL)
- Examiner, The Australasian Association of Clinical Biochemists
- Chief Examiner, The Hong Kong College of Pathologists
- Associate Editor, Clinica Chimica Acta
- Honorary Clinical Professor, Department of Obstetrics and Gynaecology
- Honorary Consultant, Department of Pathology, Queen Mary Hospital
Research Description
- The elucidation of the molecular basis of inherited human diseases through the identification of disease-causing genes
- The development of molecular diagnostics through the identification of the mutation spectrum of disease-causing genes
- Provides an effective DNA-based diagnostic protocol suitable for the 1.3-billion Chinese populations worldwide.
Research Fund
RGC General Research Fund - "Whole-Genome Linkage Analysis for Mapping a New Locus for Autosomal Dominant Hypocalcemia Using High-Density Single-Nucleotide Polymorphism Microarray"
International Media Interview
Interviewed by Russia Today on the Fukushima crisis - click here or download the .flv file here
Awards and Honors
Examination Prize, MAACB
Clinical Chemists Recognition Award, AACC
Most Outstanding Teacher Award
Fellowship, The Croucher Foundation
Best oral presentation award, AACB
Selected Publications
Click here for detail publication list on PubMed
Lam CW, Lan L, Che X, Tam S, Wong SS, Chen Y, Jin J, Tao SH, Tang XM, Yuen KY, Tam PK. Diagnosis and spectrum of melamine-related renal disease: plausible mechanism of stone formation in humans. Clin Chim Acta. 2009 Apr;402(1-2):150-5. Epub 2009 Jan 9.
Lam CW. A universal algorithm for de novo decrypting of heterozygous indel sequences: a tool for personalized medicine. Clin Chim Acta 2008;389:7-13.
Funayama M, Li Y, Tsoi TH, Lam CW, Ohi T, Yazawa S, Uyama E, Djaldetti R, Melamed E, Yoshino H, Imamichi Y, Takashima H, Nishioka K, Sato K, Tomiyama H, Kubo S, Mizuno Y, Hattori N. Familial Parkinsonism with digenic parkin and PINK1 mutations. Mov Disord. 2008; 23:1461-5.
Mak M, Lam CW, Tam S, Lai CL, Chan LY, Fan ST, Lau YL, Lai ST, Yuen P, Hui J, Wong KS, Mak WL, Kong T, Tong SF, Lau A, Leung N, Cheung KM, Chan YK, Ma O, Chan YW. Mutational analysis of 61 Wilson disease patients in Hong Kong Chinese - Identification of 17 novel mutations and its genetic heterogeneity. J Hum Genet. 2008; 53:55 - 63.
Mak CM, Lam CW, Lai ST, Hui Y, Tam S. Rapid diagnosis of Wilson disease by a 28-mutation panel: Real-time amplification refractory mutation system in diagnosing acute Wilsonian liver failure. Clin Chim Acta. 2008; 398:39-42.
Mak CM, Lam CW. Diagnosis of Wilson's disease: a comprehensive review. Crit Rev Clin Lab Sci. 2008;45:263-90.
Mak CM, Lam CW, Tam S. Diagnostic accuracy of serum ceruloplasmin in Wilson disease: determination of sensitivity and specificity by ROC curve analysis among ATP7B-genotyped subjects. Clin Chem. 2008;54:1356-62.
Mok NS, Lam CW, Fong NC, Hui YW, Choi YC, Chan KY. Cardiac ryanodine receptor gene (hRyR2) mutation underlying catecholaminergic polymorphic ventricular tachycardia in a Chinese adolescent presenting with sudden cardiac arrest and cardiac syncope. Chin Med J 2006;119:2129-33.
Lam CW, Yan MS, Law TY, Tong SF, Orrico A, Galli L, Sorrentino V, Benedetti A. Resequencing the G6PT1 gene reveals a novel splicing mutation in a patient with glycogen storage disease type 1b. Clin Chim Acta. 2006;374:147-8.
Yuen YP, Lam CW, Lai CK, Tong SF, Li PS, Tam S, Kwan EYW, Chan SY, Tsang WK, Chan KY, Mak WL, Cheng CW, Chan YW. Heterogeneous mutations in the SLC3A1 and SLC7A9 genes in Chinese patients with cystinuria. Kidney Int 2006; 69:123 - 128.
Lam CW , Cheung KM, Tsui MS, Yan MSC, Lee CY, Tong SF. A patient with novel ABCB11 gene mutations with phenotypic transition between BRIC2 and PFIC2. J Hepatol 2006; 44:240 - 242.
Lam CW, Mak CM. Allele dropout in PCR-based diagnosis of Wilson disease: mechanisms and solutions. Clin Chem 2006;52:517 - 520.
Mok NS, Lam CW, Fong NC, Hui YW, Choi YC, Chan KY. Cardiac ryanodine receptor gene (hRyR2) mutation underlying catecholaminergic polymorphic ventricular tachycardia in a Chinese adolescent presenting with sudden cardiac arrest and cardiac syncope. Chin Med J 2006; 119: 2129 - 2133.
Lam CW , Cheung KKT, Luk NM, Chan SW, Lo KK, Tong SF. DNA-based diagnosis of xeroderma pigmentosum group C by whole-genome scan using single-nucleotide polymorphism microarray. J Invest Dermatol 2005;124: 87 - 91.
Lam CW . Mutation not universally linked with diabetes. Nature 2002; 416: 677.
Lam CW, Yeung WL, Ko CH, Poon PM, Tong SF, Chan KY, Lo IF, Chan LY, Hui J, Wong V, Pang CP, Lo YM, Fok TF. Spectrum of mutations in the MECP2 gene in patients with infantile autism and Rett syndrome. J Med Genet. 2000;37:E41.
Orrico A, Lam CW, Galli L, Dotti MT, Hayek G, Tong SF, Poon PM, Zappella M, Federico A, Sorrentino V. MECP2 mutation in male patients with non-specific X-linked mental retardation. FEBS Lett. 2000;481:285-8.
Lam CW . Origin of the Japanese population. Science 1999; 284:1125.
Lam CW , Xie J, To KF, Ng HK, Lee KC, Yuen NW, Lim PL, Chan LY, Tong SF, McCormick F. A frequent activated smoothened mutation in sporadic basal cell carcinomas. Oncogene. 1999;18:833-6.
Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam CW, Hynes M, Goddard A, Rosenthal A, Epstein EH Jr, de Sauvage FJ. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 1998;391: 90 - 92.