You are now seeing our website in text only version, feel free to switch back to the default view.

Department | History | Staff | Teaching | Research | Facilities | Publications | Events

Home | Contact Us | Site Map | Default Version

Home   |   Contact Us   |   Site Map   |   Text Only
HKU Main Menu
Department History Staff Teaching Research Facilities Publications Events
STAFF

Dr HO Wai Hung, Daniel|dwhho@pathology.hku.hk

PhD HK
Research Assistant Professor

Research Interest

My research focuses are bioinformatics analyses on high-throughput omics data and computational analysis tools development. I have particular interests on genomics studies of hepatocellular carcinoma (HCC) through the application of next generation sequencing, large-scale screening and single-cell genomics. I am also involved in multidiscriplinary and integrative studies to investigate and understand the molecular mechanism of hepatocarcinogenesis and metastasis of HCC.

  • Genomic analyses of liver cancer using next generation sequencing and single-cell genomics
  • Bioinformatics development on computational analysis tools and database

Postgraduate positions are available. Please contact Dr. Daniel Ho for inquiries.

Awards and Honors

  • Young Investigator Award, 9th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2018)
  • Honorary Fellow, Hong Kong Polytechnic University (Department of Health Technology and Informatics, 2012-2014)
  • Best poster award, International Society for the Study of the Lumbar Spine – Annual Meeting 2007

Professional Activities

  • Review Editor, Frontiers in Genetics (2011-Present)
  • Reviewer for Hepatology, Bioinformatics, Genome Medicine, Oncotarget, Scientific Reports, Clinica Chimica Acta and Frontiers in Pediatrics

Professional Memberships

  • Member, International Liver Cancer Association
  • Fellow, The Royal Society of Public Health, UK
  • Associate Member, The Institute of Biomedical Science (IBMS), UK

Research Grants

Research Grants Council (RGC) – General Research Fund
- 2016 (Co-I)
- 2014 (Co-I)

Health and Medical Research Fund (HMRF)

- 2016 (PI)
- 2013 (Co-I)

National Natural Science Fund of China

  • 2019 (PI)

Recent Publications

ORCID ID: orcid.org/0000-0003-3884-296X

Book chapters

  1. Ho DW, Yip SP. Whole genome amplification: Technologies and applications. Genomics III – Methods, Techniques and Applications. 2014. iConcept Press.
  2. Cheung KMC, Ho DW, Song YQ. Chapter 4. Genetics. The Growing Spine. Management of Spinal Disorders in Young Children. Akbarnia Behrooz A., Yazici Muharrem, Thompson George H. (Eds.). 2010. Springer.

Journal articles

  1. Ho DW*, Tsui YM*, Sze KM, Chan LK, Cheung TT, Lee E, Sham PC, Tsui SK, Lee TK, Ng IO. Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and stemness-related subpopulations in liver cancer. Cancer Letters. doi:10.1016/j.canlet.2019.06.002. (*equal contribution) (IF=6.508)
  2. Ma W*, Ho DW*, Sze KM*, Tsui YM, Chan LK, Lee JM, Ng IO. APOBEC3B promoteshepatocarcinogenesis and metastasis through novel deaminase-independent activity. Mol Carcinog 2018 Dec 21. doi:10.1002/mc.22956. (*equal contribution) (IF=3.851)
  3. Tan HW, Leung CO, Chan KK, Ho DW, Leung MS, Wong CM, Ng IO, Lo R. Deregulated GATA6 modulates stem cell-like properties and metabolic phenotype in hepatocellular carcinoma. Int J Cancer. doi:10.1002/ijc.32248. (IF=7.360)
  4. Law CT, Wei L, Tsang FH, Chan CY, Xu IM, Lai RK, Ho DW, Lee JM, Wong CC, Ng IO, Wong CM. HELLS regulates chromatin remodeling and epigenetic silencing of multiple tumor suppressor genes in human hepatocellular carcinoma. Hepatology 2018 Dec 5. doi:10.1002/hep.30414. (IF=14.079)
  5. Lo RC, Leung CO, Chan KK, Ho DW, Wong CM, Lee TK, Ng IO. Cripto-1 contributes to stemness in hepatocellular carcinoma by stabilizing Dishevelled-3 and activating Wnt/β-catenin pathway. Cell Death Differ 2018 Aug;25(8):1426-1441.doi: 10.1038/s41418-018-0059-x. (IF=8.339)
  6. Chen M, Wei L, Law CT, Tsang FH, Shen J, Cheng CL, Tsang LH, Ho DW, Chiu DK, Lee JM, Wong CC, Ng IO, Wong CM. RNA N6-methyladenosine methyltransferase METTL3 promotes liver cancer progression through YTHDF2 dependent post-transcriptional silencing of SOCS2. Hepatology 2017 Nov 24. doi:10.1002/hep.29683. (IF=14.079)
  7. Ho DW*, Chan LK*, Chiu YT, Xu IM, Poon RT, Cheung TT, Tang CN, Tang VW, Lo IL, Lam PW, Yau DT, Li MX, Wong CM, Ng IO. TSC1/2 mutations define a molecular subset of HCC with aggressive behavior and treatment implication. Gut doi:10.1136/gutjnl-2016-312734. (*equal contribution) (IF=16.658; ranks 2nd in the category of Gastroenterology and Hepatology)
  8. Cui CP, Wong CC, Kai AK, Ho DW, Lau EY, Tsui YM, Chan LK, Cheung TT, Chok KS, Chan AC, Lo RC, Lee JM, Lee TK, Ng IO. SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop. Gut doi:10.1136/gutjnl-2016-313264. (IF=16.658)
  9. Chan KK, Leung CO, Wong CC, Ho DW, Chok KS, Lai CL, Ng IO, Lo RC. Secretory Stanniocalcin 1 promotes metastasis of hepatocellular carcinoma through activation of JNK signaling pathway. Cancer Letters 2017; 403:330-338. (IF=6.375)
  10. Tsui YM, Sze KM, Tung EK, Ho DW, Lee TK, Ng IO. Dishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma. Oncotarget 2017; 8:39430-39442. (IF=5.168)
  11. Chiu YT, Wong JK, Choi SW, Sze KM, Ho DW, Chan LK, Lee JM, Man K, Cherny S, Yang WL, Wong CM, Sham PC, Ng IO. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol 2016; 64:1256-64. (IF=12.486; ranks 5th in the category of Gastroenterology and Hepatology)
  12. Wong CM, Wei L, Law CT, Ho DW, Tsang FH, Au SL, Sze KM, Lee JM, Wong CC, Ng IO. Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis. Hepatology 2016; 63:474-87. (IF=13.246; ranks 4th in the category of Gastroenterology and Hepatology)
  13. Ho DW, Lo RC, Chan LK, Ng IO. Molecular pathogenesis of hepatocellular carcinoma. Liver Cancer 2016; 5:290-302. (IF=7.854)
  14. Ho DW, Sze MF, Ng IO. Virus-Clip: a fast and memory-efficient viral integration site detection tool at single-base resolution with annotation capability. Oncotarget 2015; 6:20959-63. (IF=5.168)
  15. Ho DW, Ng IO. uGPA: unified Gene Pathway Analyzer package for high-throughput genome-wide screening data provides mechanistic overview on human diseases. Clinica Chimica Acta 2015; 441:105-108. (IF=2.873)
  16. Ho DW, Kai AK, Ng IO. TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma. Front Med 2015; 9:322-30. (IF=1.634)
  17. Ho DW, Mak VT, Kwok TC, Au AM, Ho FK. Development of a web-based training program for dementia caregivers in Hong Kong. Clin Gerontol 2015; 38:211-223. (IF=0.593)
  18. Kwok T, Ho DW, Chan G, Ip I, Wong B, Ho F. Evaluation of day care services for demented clients in Hong Kong. Asian J Gerontol Geriatrics 2014; 9:5-9.
  19. Bai X, Ho DW, Fung K, Tang L, He M, Young D, Kwok T, Ho F. Effectiveness of a Life Story Work program on Older Adults with Intellectual Disabilities. Clin Interv Aging 2014; 9:1865-72. (IF=2.581)
  20. Verhoeven VJ, Hysi PG, Wojciechowski R, Fan Q, Guggenheim JA, Höhn R, MacGregor S, Hewitt AW, Nag A, Cheng CY, Yonova-Doing E, Zhou X, Ikram MK, Buitendijk GH, McMahon G, Kemp JP, Pourcain BS, Simpson CL, Mäkelä KM, Lehtimäki T, Kähönen M, Paterson AD, Hosseini SM, Wong HS, Xu L, Jonas JB, Pärssinen O, Wedenoja J, Yip SP, Ho DW, Pang CP, Chen LJ, Burdon KP, Craig JE, Klein BE, Klein R, Haller T, Metspalu A, Khor CC, Tai ES, Aung T, Vithana E, Tay WT, Barathi VA; Consortium for Refractive Error and Myopia (CREAM), Chen P, Li R, Liao J, Zheng Y, Ong RT, Döring A; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group, Evans DM, Timpson NJ, Verkerk AJ, Meitinger T, Raitakari O, Hawthorne F, Spector TD, Karssen LC, Pirastu M, Murgia F, Ang W; Wellcome Trust Case Control Consortium 2 (WTCCC2), Mishra A, Montgomery GW, Pennell CE, Cumberland PM, Cotlarciuc I, Mitchell P, Wang JJ, Schache M, Janmahasatian S, Igo RP Jr, Lass JH, Chew E, Iyengar SK; Fuchs' Genetics Multi-Center Study Group, Gorgels TG, Rudan I, Hayward C, Wright AF, Polasek O, Vatavuk Z, Wilson JF, Fleck B, Zeller T, Mirshahi A, Müller C, Uitterlinden AG, Rivadeneira F, Vingerling JR, Hofman A, Oostra BA, Amin N, Bergen AA, Teo YY, Rahi JS, Vitart V, Williams C, Baird PN, Wong TY, Oexle K, Pfeiffer N, Mackey DA, Young TL, van Duijn CM, Saw SM, Bailey-Wilson JE, Stambolian D, Klaver CC, Hammond CJ. Genome-wide meta-analyses of multi-ethnic cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet 2013; 45:314-8. (IF=27.959)
  21. Song YQ, Karasugi T, Cheung KMC, Chiba K, Ho DW, Miyake A, et al. Identification of a functional variant in CHST3 associated with the susceptibility for lumbar disc degeneration. J Clin Invest 2013; 123:4909-17. (IF=12.784)
  22. Kwok TC, Wong AY, Chan GM, Shiu RY, Lam KC, Young DK, Ho DW, Ho FK. Effectiveness of Cognitive Training for Chinese Older Adults in Hong Kong. Clin Interv Aging 2013; 8:213-9. (IF=2.581)
  23. Kwok T, Leung PC, Wing YK, Ip I, Wong B, Ho DW, Wong WM, Ho F. The effectiveness of acupuncture on the sleep quality of elderly with dementia: A within-subjects trial. Clin Interv Aging 2013; 8:923-9. (IF=2.581)
  24. Ho DW, Yiu WC, Yap MK, Fung WY, Ng PW, Yip SP. Association of High Myopia with Crystallin Beta A4 (CRYBA4) Gene Polymorphisms in the Linkage-identified MYP6 Locus. PLoS ONE 2012; 7:e40238. (IF=2.806)
  25. Ho DW, Yap MK, Yip SP. UPDG: Utilities package for data analysis of pooled DNA GWAS. BMC Genetics 2012; 13:1. (IF=2.266)
  26. Kwok TC, Bai X, Chui MY, Lai CK, Ho DW, Ho FK, Woo J. Effect of physical restraint reduction on older patients’ hospital length of stay. J Am Med Dir Assoc 2012; 13:645-50. (IF=5.775)
  27. Zhu M, Yap MK, Ho DW, Fung WY, Ng PW, Gu Y, Yip SP. The UMODL1 gene as a susceptibility gene for high myopia: a case-control association study in Chinese. BMC Med Genet 2012; 13:64. (IF=2.198)
  28. Ho DW, Yiu WC, Yap MK, Fung WY, Ng PW, Yip SP. Genotyping performance assessment of whole genome amplified DNA with respect to multiplexing level of assay and its period of storage. PLoS ONE 2011; 6:e26119. (IF=2.806)
  29. Cheung KMC, Samartzis D, Karppinen J, Mok FPS, Ho DW, Fong, DYT, Luk KDK. Intervertebral disc degeneration: new insights based on "skipped" level disc pathology. Arthritis Rheum 2010; 62:2392-400. (IF= 6.918)
  30. Cheung KM, Karppinen J, Chan D, Ho DW, Song YQ, Sham P, Cheah KS, Leong JC, Luk KD. Prevalence and pattern of lumbar magnetic resonance imaging changes in a population study of one thousand forty-three individuals. Spine 2009; 34:934-40. (IF=2.499)
  31. Song YQ*, Ho DW*, Karppinen J, Kao PY, Fan BJ, Luk KD, et al. Association between promoter -1607 polymorphism of MMP1 and Lumbar Disc Disease in Southern Chinese. BMC Med Genet 2008; 9:38. (*equal contribution) (IF=2.198)
  32. Song YQ, Cheung KM, Ho DW, Poon SC, Chiba K, Kawaguchi Y, Hirose Y, Alini M, Grad S, Yee AF, Leong JC, Luk KD, Yip SP, Karppinen J, Cheah KS, Sham P, Ikegawa S, Chan D. Association of the asporin D14 allele with lumbar-disc degeneration in Asians. Am J Hum Genet 2008; 82:744-7. (IF=9.025)
  33. Ho DW, Chan D, Cheung KM, Sham P, Song YQ. Family-based linkage and case-control association studies. Curr Orthop 2008; 22:245-50. (IF=0.288)
  34. Virtanen IM, Song YQ, Cheung KM, Ala-Kokko L, Karppinen J, Ho DW, Luk KD, Yip SP, Leong JC, Cheah KS, Sham P, Chan D. Phenotypic and population differences in the association between CILP and lumbar disc disease. J Med Genet 2007; 44:285-8. (IF=5.451)