Dr KO Chi Fat, Frankie | frankieko@pathology.hku.hk
BSc (Hons), MPhil, PhD HK
Research Interest
My research interest is to delineate molecular regulations of tumor suppressors in hepatocellular carcinoma (HCC) development.
Recent Publication Lists
Ko F.C.F., Chan L.K., Tung E.K.K., Lowe S.W., Ng I.O.L., Yam J.W.P. Akt phosphorylation of Deleted in Liver Cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis. Gastroenterology 2010 (in press).
Ko F.C.F., Yeung Y.S., Wong C.M., Chan L.K., Poon R.T.P., Ng I.O.L., Yam J.W.P. DLC1 isoforms are distinctly expressed in human tissues, functionally different and under differential transcriptional regulation in HCC. Liver Int. 2010 30:139-148.
Chan L.K., Ko F.C.F., Ng I.O.L., Yam J.W.P. Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for tensin2 PTB domain interaction and is required for tumor suppressive function. PLoS ONE. 2009 4:e5572.
Wong C.C.L., Wong C.M., Ko F.C.F., Chan L.K., Ching Y.P., Yam J.W.P., Ng I.O.L. 2008. Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma. PLoS ONE. 2009 3:e2779.
Wong Y.F., Ko F.C.F., Cheah K.S.E., Chow K.L. crm-1 facilitates BMP signaling to control body size in Caenorhabditis elegans. Dev Biol. 2007 311:95-105.
Yam J.W.P., Ko F.C.F., Chan C.Y., Yau T.O., Tung E.K.K., Leung T.H.Y., Jin D.Y., Ng I.O.L. Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma. Hepatology. 2006 44:881-890.
Yam J.W.P., Ko F.C.F., Chan C.Y., Jin D.Y., Ng I.O.L. Interaction of DLC1-tensin2 complex with caveolin-1 and implications in tumor suppression. Cancer Res. 2006 66:8367-8372.
Ko F.C.F. and Chow K.L. A mutation at the start codon defines the differential requirement of dpy-11 in C. elegans body hypodermis and male tail. Biochem Biophys Res Commun. 2003 309:201-208.
Ko F.C.F. and Chow K.L. A novel thioredoxin-like protein encoded by C. elegans dpy-11 gene is required for body and sensory organ morphogenesis. Development. 2002 129:1185-1194.
Ko F.C.F. and Chow K.L. Mutations with sensory ray defect unmask cuticular glycoprotein antigens in Caenorhabditis elegans male tail. Dev Growth Differ. 2000 42:69-77.