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Dr CHAN Yuen Kwong, Kelvin
Research Assistant Professor/Honorary Assistant Professor
BSc Canada, PhD HK
Personal homepage:

Genetics and Epigenetics in Cancer

Research Interest

My current field of research is on genetics and epigenetics of human cancers and infectious diseases, especially hepatoceullar carcinoma (HCC) and hepatitis B.

Genetic epidemiological study for cancers (e.g. HCC) and infectious diseases (e.g. hepatitis B):

Epigenetic study:

microRNA study:

Study of the HBx gene of HBV in the host genetics and transcriptome.


Recent Publication List:

Click here for detail publication list on PubMed

Chan KY, Xu MS, Ching JC, So TM, Lai ST, Chu CM, Yam LY, Wong AT, Chung PH, Chan VS, Lin CL, Sham PC, Leung GM, Peiris JS, Khoo US. The CD209 (DC-SIGN) -336A>G promoter polymorphism and Severe Acute Respiratory Syndrome (SARS) in Hong Kong Chinese. Hum Immunol. 2010 Mar 29. [Epub ahead of print]

Ching JC*, Chan KY*, Lee HK, Xu MS, Ting KP, Sham P, Leung GM Peiris JS, Khoo US. Promoter single nucleotide polymorphisms of myxovirus resistance-A (MxA) in severe acute respiratory syndrome infection susceptibility. *both authors equally contributed to this work. Journal of Infectious Diseases (accepted).

Chan KY*, Liu W*, Long JR, Yip SP, Chan SY, Shu XO, Chua DT, Cheung AN, Chung JC, Cai H, Au GK, Chan M, Foo W, Ngan HY, Ngan ES, Garcia-Barcelo MM, Gao YT, Zheng W, Khoo US. Functional polymorphism in the promoter of BRCA1 influences transcription and is associated with decreased risk for breast cancer in Chinese women. Journal of Medical Genetics. *both authors equally contributed to this work. 2009, 46(1): 32-9.

Siu MK, Wong ES, Chan HY, Kong DS, Woo NW, Tam KF, Ngan HY, Chan QK, Chan DC, Chan KY, Cheung AN. Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion. Int J Cancer. 2009 Oct 28. [Epub ahead of print]

Khoo US, Chan KY, Ching JC, Chan VS, Ip YC, Yam L, Chu CM, Lai ST, So KM, Wong TY, Chung PH, Tam P, Yip SP, Sham P, Leung GM, Lin CL, Peiris JS. Functional role of ICAM-3 polymorphism in genetic susceptibility to SARS infection. Hong Kong Med J. 2009 Oct;15 Suppl 6:26-9.

Khoo US, Chan KY, Chan VS, Ching JC, Yam L, Chu CM, Lai ST, Wong TY, Tam P, Yip SP, Leung GM, Lin CL, Peiris JS. Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections. Hong Kong Med J. 2008 Aug;14 Suppl 4:31-5.

Khoo US, Chan KY, Chan VS, Lin CL. DC-SIGN and L-SIGN: the SIGNs for Infection. Journal of Molecular Medicine 2008 Aug; 86(8):861-74.

Siu MK, Wong ES, Chan HY, Ngan HY, Chan KY, Cheung AN. Overexpression of NANOG in gestational trophoblastic diseases: effect on apoptosis, cell invasion, and clinical outcome. American Journal of Pathology. 2008; 173(4): 1165-72.

Liao XY, Siu MK, Chan KY, Wong ES, Ngan HY, Chan QK, Li AS, Khoo US, Cheung AN. Hypermethylation of RAS effector related genes and DNA methyltransfeRASe 1 expression in endometrial carcinogenesis. International Journal of Cancer 2008; 123(2): 296-302..

Liu SS, Tsang PC, Chan KY, Cheung AN, Chan KK, Leung RC, Ngan HY. Distribution of six oncogenic types of human papillomavirus and type 16 integration analysis in Chinese women with cervical precancerous lesions and carcinomas. Tumor Biology. 2008; 29(2): 105-13.

Leung RC, Liu SS, Chan KY, Tam KF, Chan KL, Wong LC, Ngan HY. Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer. Oncology Reports 2008; 19(5):1339-45

Chan HY, Siu MK, Zhang HJ, Wong ES, Ngan HY, Chan KY, Cheung AN. Activated Stat3 expression in gestational trophoblastic disease: correlation with clinicopathological parameters and apoptotic indices. Histopathology 2008; 53(2): 139-46.

Zhang HJ, Siu MK, Wong ES, Wong KY, Lee AS, Chan KY, Ngan HY, Cheung AN. Oct4 is Epigenetically Regulated by Methylation in Normal Placenta and Gestational Trophoblastic Disease. Placenta 2008; 29(6): 549-554.

Li AS, Siu MK, Zhang HJ, Wong ES, Chan KY, Ngan HY, Cheung AN. Hypermethylation of SOX2 gene in hydatidiform mole and Choriocarcinoma. Reproductive Sciences (renamed from J of the Society for Gyn Investigation) 2008; 15(7): 735-44.

Chen Y, Chan VSF, Zheng B, Chan KY, Xu X, To LY, Huang FP, Khoo US, Lin CL. A novel subset of putative stem/progenitor CD34 +Oct-4 + cells is the major target for SARS coronavirus in human lung. Journal of Experimental Medicine 2007; 204:2529-36.

Chan KY , Ching JC, Xu MS, Cheung AN, Yip SP, Yam LY, Lai ST, Chu CM, Wong AT, Song YQ, Huang FP, Liu W, Cheung PH, Leung GM, Chow EYra YD Chow5, Eric YT Chan, Jane CK Chan, Hextan Ngan, Paul Tam, Li-Chong Chan, Pak Sham, Vera SF Chan, Malik Peiris, Steve CL Lin, Khoo US. Association of ICAM3 genetic variant with Severe Acute Respiratory Syndrome (SARS) Journal of Infectious Diseases 2007; 196:271-280.

Chan KY , Chan VSF, Chen Y, Yip SP, Lin CL #, Khoo US #. Reply to “Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection”. Nature Genetics 2007 Jun; 39(6):694-6. #corresponding authors.

Chan VSF*, Chan KY*, Chen Y*, Poon LL, Cheung ANY, Zheng B, Chan KH, Wong KKY, Mak W, Ngan HYS, Xu S, Screaton S, Chan LC, Tam PKH, Austyn JM, Yip SP, Peiris MJ, Khoo US #, Lin CL #. Homozygous L-SIGN plays a protective role in SARS-CoV infection. Nature Genetics 2006; 38:38-46. *authors equally contributed to this work, #corresponding authors.

Liu SS, Chan KY, Cheung AN, Liao XY, Leung TW, Ngan HY. Expression of DeltaNp73 and TAp73alpha independently associated with radiosensitivities and prognoses in cervical squamous cell carcinoma. Clinical Caner Research 2006 Jul 1;12(13):3922-7

Liu SS, Chan KY, Leung RC, Law HK, Leung TW, Ngan HY. Enhancement of the radiosensitivity of cervical cancer cells by overexpressing p73alpha. Molecular Cancer Ther. 2006; 5(5):1209-15.

Yang CQ*, Chan KY*, Ngan HY, Khoo US, Chiu PM, Chan QK, et al. Single nucleotide polymorphisms of follicle stimulating hormone receptor are associated with ovarian cancer susceptibility. Carcinogenesis 2006 Jul; 27(7):1502-6. *both authors equally contributed to this work.

Fong PY, Xue WC, Ngan HY, Chiu PM, Chan KY, Tsao SW, Cheung AN. Caspase activity is downregulated in choriocarcinoma: a cDNA array differential expression study. J Clin Pathol. 2006; 59:179-83.

Xue WC, Feng HC, Chan KY, Chiu PM, Ngan HY, Khoo US, Tsao SW, Chan KW, Cheung AN. Id helix-loop-helix proteins are differentially expressed in gestational trophoblastic disease. Histopathology. 2005 Sep;47(3):303-9.

Shen DH*, Chan KY*, Khoo US, Ngan HY, Xue WC, Chiu PM, Ip PP, Cheung AN. Epigenetic and genetic alterations of p33ING1b in ovarian cancer. Carcinogenesis 2005 Apr; 26(4):855-63. *both authors equally contributed to this work.

Chan QK, Khoo US, Ngan HY, Yang CQ, Xue WC, Chan KY, Chiu PM, Ip PP, Cheung AN. Single Nucleotide Polymorphism of pi-class G lutathione-S-transferase and Susceptibility to Endometrial Carcinoma. Clinical Cancer Research 2005 Apr 15; 11(8):2981-5.

Chan QK, Khoo US, Chan KY, Ngan HY, Li SS, Chiu PM, Man LS, Ip PP, Xue WC, Cheung AN. Promoter Methylation and Differential Expression of pi-class G lutathione-S-Transferase in Endometrial Carcinoma. J Mol Diagn. 2005 Feb; 7(1):8-16.

Li SS, Xue WC, Khoo US, Ngan HY, Chan KY, Tam IY, Chiu PM, Ip PP, Tam KF, Cheung AN. Replicative MCM7 protein as a proliferation marker in endometrial carcinoma: A tissue microarray and clinicopathologic analysis. Histopathology 2005 Mar; 46(3):307-13.

Fong PY, Xue WC, Ngan HY, Chan KY, Khoo US, Tsao SW, Chiu PM, Man LS, Cheung AN. Mcl-1 expression in gestational trophoblastic disease correlates with clinical outcome. Cancer. 2005 Jan 15; 103(2):268-76.

Xue WC*, Chan KY*, Feng HC, Chiu PM, Ngan HY, Tsao SW, Cheung AN. Promoter hypermethylation of multiple genes in hydatidiform mole and choriocarcinoma. J Mol Diagn. 2004 Nov; 6(4):326-34. *both authors equally contributed to this work.

Liu SS, Leung RC, Chan KY, Chiu PM, Cheung AN, Tam KF, Ng TY, Wong LC, Ngan HY. p73 expression is associated with the cel lular radiosensitivity in cervical cancer after radiotherapy. Clinical Cancer Research. 2004 May 15; 10(10):3309-16.

Yang HJ, Liu VW, Wang Y, Chan KY, Tsang PC, Khoo US, Cheung AN, Ngan HY. Detection of hypermethylated genes in tumor and plasma of cervical cancer patients. Gynecol Oncol. 2004 May; 93(2):435-40.

Cheung AN, Szeto EF, Ng KM, Fong KW, Yeung AC, Tsun OK, Khoo US, Chan KY, Ng AW. Atypical squamous cells of undetermined significance on cervical smears: follow-up study of an Asian screening population. Cancer. 2004 Apr 25;102(2):74-80.

Xue WC, Khoo US, Ngan HY, Chan KY, Ip PP, Tsao SW, Cheung AN. c-mos immunoreactivity aids in the diagnosis of gestational trophoblastic lesions. Int J Gynecol Pathol. 2004 Apr; 23(2):145-50.

Cheung AN, Khoo US, Lai CY, Chan KY, Xue WC, Cheng DK, Chiu PM, Tsao SW, Ngan HY. Metastatic trophoblastic disease after an initial diagnosis of partial hydatidiform mole: genotyping and chromosome in situ hybridization analysis. Cancer. 2004 Apr 1;100(7):1411-7.

Xue WC, Feng HC, Tsao SW, Chan KY, Ngan HY, Chiu PM, Maccalman CD, Cheung AN. Methylation status and expression of E-cadherin and cadherin-11 in gestational trophoblastic diseases. Int J Gynecol Cancer. 2003 Nov-Dec; 13(6):879-88.

Xue WC, Khoo US, Ngan HY, Chan KY, Chiu PM, Tsao SW, Cheung AN. Minichromosome maintenance protein 7 expression in gestational trophoblastic disease: correlation with Ki67, PCNA and clinicopathological parameters. Histopathology. 2003 Nov; 43(5):485-90.

Lai CY, Chan KY, Khoo US, Ngan HY, Xue WC, Chiu PM, Tsao SW, Cheung AN. Analysis of gestational trophoblastic disease by genotyping and chromosome in situ hybridization. Mod Pathol. 2004 Jan; 17(1):40-48.

Chan KY , Cheung AN, Yip SP, Ko HH, Lai TW, Khoo US. Population-based case-control study of HER2 genetic polymorphism and breast cancer risk. Journal of National Cancer Institute. 2002 Oct 16; 94(20):1581-2. No abstract available.

Chan KY , Ozcelik H, Cheung AN, Ngan HY, Khoo US. Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer. Cancer Research. 2002 Jul 15; 62(14):4151-6.

Khoo US, Chan KY, Cheung AN, Xue WC, Shen DH, Fung KY, Ngan HY, Choy KW, Pang CP, Poon CS, Poon AY, Ozcelik H. Recurrent BRCA1 and BRCA2 germline mutations in ovarian cancer: a founder mutation of BRCA1 identified in the Chinese population. Hum Mutataion. 2002 Mar; 19(3):307-8.

Shen DH, Khoo US, Xue WC, Ngan HY, Wang JL, Liu VW, Chan YK, Cheung AN. Primary peritoneal malignant mixed Mullerian tumors. A clinicopathologic, immunohistochemical, and genetic study. Cancer. 2001 Mar 1; 91(5):1052-60.

Khoo US, Ngan HY, Cheung AN, Chan KY, Lu J, Chan VW, Lau S, Andrulis IL, Ozcelik H. Mutational analysis of BRCA1 and BRCA2 genes in Chinese ovarian cancer identifies 6 novel germline mutations. Hum Mutation. 2000 Jul; 16(1):88-9.