Research Interest
My research focuses are the mechanistic study of liver cancer initiation and progression. With the conditional degron and transcriptional control, we developed the conditional inactivation system imitating the conditional knockout in cells but with astonishing speed to deplete the protein of interest. In additional to mechanistic study, we also involved in characterizing the role of human genes (such as TRIP13) in HBV life cycle.
Research Grants
2020-2022 Food and Health Bureau – HMRF
Title: Role of TRIP13 gene in hepatocellular carcinoma development and disease progression
2020-2022 UGC - General Research Fund
Title: Investigating the novel roles of TRIP13 in MDM2/MDM4-p53 regulation
2018-2020 UGC - General Research Fund
Title: Understanding the role of TRIP13 and MAD2 conformation equilibrium in spindle assembly checkpoint
2017-2019 Food and Health Bureau – HMRF
Title: Aberrant spindle-assembly checkpoint, chromosomal instability, and liver cancer
Publications
https://www.scopus.com/authid/detail.uri?authorId=16175312000
(as of 2021 September)
- Lau H.W., Ma H.T. #, Yeung T.K., Tam M. Y., Zheng D., Chu S. K., and Poon R.Y.C. (2021) The unique functions of CDK1 in human cells is due to quantitative rather than qualitative differences with CDK2. Cell Rep in press
- Yeung T.K., Lau H.W., Ma H.T. *, and Poon R.Y.C. (2021) One-step multiplex toolkit for efficient generation of conditional gene silencing human cell lines. Mol Bio Cell 32(14):1320-1330.
- Ma H.T. and Poon RYC (2020) Aurora kinases and DNA damage response. Mutat Res 821: 111716.
- Mak J.P.Y., Ma H.T., and Poon R.Y.C. (2020) Synergism between ATM and PARP1 inhibition involves DNA damage and abrogating the G2 DNA damage checkpoint. Mol Cancer Ther 19: 123-134.
- Lok, T.S., Wang, Y., Xu, W.K., Xie, S., Ma, H.T., and Poon, R.Y.C. (2020) Mitotic slippage is determined by p31comet and the weakening of the spindle-assembly checkpoint. Oncogene 39: 2819-34.
- Mak, J.P.Y., Ma, H.T., and Poon, R.Y.C. (2019) Synergism between ATM and PARP1 inhibition involves DNA damage and abrogating the G2 DNA damage checkpoint.Mol Cancer Ther. 19: 123-134.
- Zeng, X., Xu, W.K., Lok T.M., Ma, H.T., and Poon, R.Y.C. (2019) Imbalance of the spindle-assembly checkpoint promotes spindle poison-mediated cytotoxicity with distinct kinetics.Cell Death Dis. 10(4):314.
- Ng, L.Y., Ma, H.T.*, Liu, J.C.Y., Huang, X., Lee, N., and Poon, R.Y.C. (2019) Conditional gene inactivation by combining tetracycline-mediated transcriptional repression and auxin-inducible degron-mediated degradation. Cell Cycle 18: 238-48.
- Ma, H.T. and Poon, R.Y.C. (2018) TRIP13 Functions in the Establishment of the Spindle Assembly Checkpoint by Replenishing O-MAD2. Cell Rep 22(6):1439-50.
- Ma, H.T. and Poon, R.Y.C. (2016) TRIP13 regulates both the activation and inactivation of the spindle-assembly checkpoint. Cell Rep 14(5):1086-99.