My current research is focused on:

• Identification and characterization of functional molecular targets in liver diseases

• Icahn School of Medicine at Mount Sinai, New York
• Institute of Liver Studies, King’s College Hospital, London 

Researcher Profile on HKU Scholars Hub

• Chan KK, Au K, Suen L, Leung B, Wong C, Leow W, Lim TK, Ng IO, Chung CY, Lo RC. Sortilin-driven cancer secretome enhances tumorigenic properties of hepatocellular carcinoma via de novo lipogenesis.  Am J Pathol. (accepted for publication)
  
  
• Chan KK, Au KY, Fung WC, Wong CY, Chan AC, LO RC. A sex-specific analysis of microRNA profiles in hepatitis B virus-associated cirrhosis by small RNA-sequencing. Hepatol Commun. 2022 Dec;6(12):3473-3486.
  
  
• Chan KK, Hon TC, Au KY, Choi HL, Wong DK, Chan AC, Yuen MF, Lai CL, Lo RC. Stanniocalcin 1 is a serum biomarker and potential therapeutic target for HBV-associated liver fibrosis. J Pathol. 2022 Jun;257(2):227-238.
  
  
• Leung MS, Chan KK, Dai WJ, Wong CY, Au KY, Wong PY, Wong CC, Lee TK, Ng IO, Kao WJ, Lo RC. Anti-tumour effects of PIM kinase inhibition on progression and chemoresistance of hepatocellular carcinoma. J Pathol. 2020 Sep;252(1):65-76.
  
  
• Tan HW, Leung CO, Chan KK, Ho DW, Leung MS, Wong CM, Ng IO, Lo RC. Deregulated GATA6 modulates stem cell-like properties and metabolic phenotype in hepatocellular carcinoma. Int J Cancer. 2019 Oct 1;145(7):1860-1873. 
  
  
• Lo RC, Leung CO, Chan KK, Ho DW, Wong CM, Lee TK, Ng IO. Cripto-1 contributes to stemness in hepatocellular carcinoma by stabilizing Dishevelled-3 and activating Wnt/β-catenin pathway. Cell Death Differ. 2018 Aug;25(8):1426-1441.
  
  
• Chan KK, Leung CO, Wong CC, Ho DW, Chok KS, Lai CL, Ng IO, Lo RC. Secretory Stanniocalcin 1 promotes metastasis of hepatocellular carcinoma through activation of JNK signaling pathway. Cancer Lett. 2017 Sep 10;403:330-338.
  
  
• Leung CO, Mak WN, Kai AK, Chan KS, Lee TK, Ng IO, Lo RC. Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling. Oncotarget. 2016 May 17;7(20):29371-86.
  
  
• Leung CO, Wong CC, Fan DN, Kai AK, Tung EK, Xu IM, Ng IO, Lo RC. PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma. Oncotarget. 2015 May 10;6(13):10880-92.

• Kristy Chan (Assistant Research Officer)
• Emily Cheng (Research Assistant)
• Alfred Suen (Research Assistant)
• Joyce Zhang (Research Assistant)
• Jenny Fung (MPhil Student)
• Nelson Yip (MPhil Student)
• Kwan-Ting Lam (MMedSc Student)

• Awardee, Clinical Research Fellowship Scheme 2016/17, Research Grants Council, Hong Kong
• Junior Investigator Award, International Liver Cancer Association Annual Conference 2015
• Distinguished Young Fellow 2015, The Hong Kong Academy of Medicine
  

• Health and Medical Research Fund (HMRF), Hong Kong – 2016, 2018, 2019, 2021
• General Research Fund (GRF), Research Grants Council, Hong Kong - 2016

Number of students with completed studies

• MPhil/PhD program: 7
• MMedSc program: 10