Professor Ip was a medical graduate of University of Glasgow, Scotland and was trained in anatomical pathology at the University of Hong Kong. He completed his gynecologic pathology fellowship under Dr Philip B Clement at the Vancouver General Hospital, University of British Columbia, and under Dr Robert H Young at the Massachusetts General Hospital, Harvard Medical School, Boston. Professor Ip has presented widely and internationally, and authored papers, book chapters, and clinical management guidelines in the field of gynecologic pathology, including multiple chapters in the 4th Edition of World Health Organization Classification of Tumours of Female Reproductive Organs (2014), 5th and 6^th Editions of World Health Organization Classification of Female Genital Tumours (2020 and 2026). Professor Ip’s career interests include uterine smooth muscle neoplasms, in particular molecular basis of uterine leiomyosarcoma and therapeutic strategies, and smooth muscle tumor of uncertain malignant potential. His other interests include uncommon endometrial carcinomas and tumor-like lesions.

• The International Society of Gynecological Pathologists Board of Directors
• The International Society of Gynecological Pathologists Research Committee
• International Federation of Gynecology and Obstetrics (FIGO) Committee on Women’s Cancer (subcommittee on Endometrial Cancer)
• International Consensus Group for HER2 Testing in Gynecologic Tumors
• International Collaboration in Cancer Reporting Domain Expert Panel: Endometrial Cancers
• International Collaboration in Cancer Reporting Domain Expert Panel: Uterine Malignant and Potentially Malignant Mesenchymal Tumours
• The International Society of Gynecological Pathologists Global Advisory Network (Asia-East)
• International Academy of Pathology, Hong Kong Division, Council
• The Hong Kong College of Pathologists, Anatomical Pathology Examiner (former Chief Examiner, and Genetic and Genomic Pathology First Fellowship Assessor), and Laboratory Inspector for Training
  
   

• Chairman of Hong Kong Pathology Forum
• MBBS IV Chief Examiner in Pathology
• Teaching topics on Female Reproductive Tract Pathology, Endocrine Pathology, and Cytopathology
  
   

• American Journal of Surgical Pathology
• International Journal of Gynecological Pathology

• Health and Medical Research Fund (08192396): Therapeutic potentials of polo-like kinase 4 inhibitor in leiomyosarcoma.
• Health and Medical Research Fund (09201856): Improved patient management through genomic analysis of uterine smooth muscle tumor of uncertain malignant potential (STUMP).

Uterine Smooth Muscle Tumor

• Lee HHY, Chow KL, Wong HS, Chong TY, Wong AST, Cheng GHW, Ko JMK, Siu HC, Yeung MCF, Huen MSY, Tse KY, Bray MR, Mak TW, Leung SY, Ip PPC. Inhibition of aberrantly overexpressed Polo-like kinase 4 is a potential effective treatment for DNA damage repair-deficient uterine leiomyosarcoma. Clin Cancer Res. 2024. https://aacrjournals.org/clincancerres/article/doi/10.1158/1078-0432.CCR-23-3720/745818/Inhibition-of-aberrantly-overexpressed-Polo-like
• Lok J, Tse KY, Lee EYP, Wong RWC, Cheng ISY, Chan ANH, Leung CKL, Cheung ANY, Ip PPC. Intraoperative frozen section biopsy of uterine smooth muscle tumors: A clinicopathologic analysis of 112 cases with emphasis on potential diagnostic pitfalls. Am J Surg Pathol. 2021;45:1179-1189.
• Ip PP, Cheung AN, Clement PB. Uterine smooth muscle tumor of uncertain malignant potential. A clinicopathologic study of 16 cases. Am J Surg Pathol. 2009;33:992-1005.
• Ip PP, Tse KY, Tam KF. Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy. Adv Anat Pathol. 2010;17:91-112.
• Ip PP, Lim D, Cheung ANY, Oliva E. Immunoexpression of p16 in uterine leiomyomas with infarct-type necrosis: an analysis of 35 cases. Histopathology. 2017;71:743-750.
• Chow KL, Tse KY, Cheung CL, Wong KW, Cheung AN, Wong RW, Chan AN, Yuen NW, Ngan HY, Ip PP. The mitosis-specific marker phosphohistone-H3 (PHH3) is an independent prognosticator in uterine smooth muscle tumours: an outcome-based study. Histopathology. 2017;70:746-755.
• Ip PP, Cheung AN. Pathology of uterine leiomyosarcomas and smooth muscle tumours of uncertain malignant potential. Best Pract Res Clin Obstet Gynaecol. 2011;25:691-704.
• Slatter TL, Hsia H, Samaranayaka A, Sykes P, Clow WB, Devenish CJ, Sutton T, Royds JA, Ip PP, Cheung AN, Hung NA. Loss of ATRX and DAXX expression identifies poor prognosis for smooth muscle tumours of uncertain malignant potential and early stage uterine leiomyosarcoma. J Pathol Clin Res. 2015;1:95-105.
• Ip PP, Lam KW, Cheung CL, Yeung MC, Pun TC, Chan QK, Cheung AN. Tranexamic acid-associated necrosis and intralesional thrombosis of uterine leiomyomas: a clinicopathologic study of 147 cases emphasizing the importance of drug-induced necrosis and early infarcts in leiomyomas. Am J Surg Pathol. 2007;31:1215-24.
• Tse KY, Wong RWC, Chao A, Ueng SH, Yang LY, Cummings M, Smith D, Lai CR, Lau CR, Lau HY, Yen MS, Cheung ANY, Leung CKL, Chan KS, Chan ANH, Li HW, Choi CKM, Pong WM, Hui HF, Yuk JYW, Yao H, Yuen NWF, Obermair A, Lai CH, Ip PPC, Ngan HYS. Development of a multi-institutional prediction model for three-year survival status in patients with uterine leiomyosarcoma (AGOG11-022 / QCGC1302 study). Cancers (Basel). 2021;13 (10):2378.

Endometrial Carcinoma And Tumor-Like Lesions

• Li JJX, Chui MH, McCluggage WG, Fadare O, Cheng GHW, Ko JMK, Dungog CC, Lee JHS, Ma ESK, Tse KY, Ip PPC. Endometrial carcinomas with a somatically-derived yolk sac tumor component share molecular similarities to p53-abnormal endometrial carcinomas and germ cell tumors. Mod Pathol 2026;39(4):100976. DOI: 10.1016/j.modpat.2026.100976.
• Li JJX, Ip PPC. Endometrial cancer. An update on prognostic pathologic features and clinically relevant biomarkers. Surg Pathol Clin 2022;15(2):277–299.
• Ip PP. Benign endometrial proliferations mimicking malignancies: a review of problematic entities in small biopsy specimens. Virchows Arch. 2018;472:907-917.
• Ip PP, Wang SY, Wong OGW, Chow KL, Lee HHY, Cheung ANY, Tse KY. Napsin A, hepatocyte nuclear factor-1-beta (HNF-1β), estrogen and progesterone receptors expression in Arias-Stella reaction. Am J Surg Pathol. 2019;43:325-333.
• Ip PP, Irving JA, McCluggage WG, Clement PB, Young RH. Papillary proliferation of the endometrium: a clinicopathologic study of 59 cases of simple and complex papillae without cytologic atypia. Am J Surg Pathol. 2013;37:167-77.
• Jamieson A, Vermij L, Kramer CJH, Jobsen JJ, Jürgemlienk-Schulz I, Lutgens L, Mens JW, Haverkort MAD, Slot A, Nout RA, Oosting J, Carlson J, Howitt BE, Ip PPC, Lax SF, McCluggage WG, Singh N, McAlpine JN, Creutzberg CL, Horeweg N, Gilks CB, Bosse T. Clinical behavior and molecular landscape of stage I p53-abnormal low-grade endometrioid endometrial carcinomas. Clin Cancer Res. 2023;29(23):4949-4957.
• Lim D, Ip PP, Cheung AN, Kiyokawa T, Oliva E. Immunohistochemical comparison of ovarian and uterine endometrioid carcinoma, endometrioid carcinoma with clear cell change, and clear cell carcinoma. Am J Surg Pathol. 2015;39:1061-9.
• Fadare O, Shaker N, Alghamdi A, Ganesan R, Hanley KZ, Hoang LN, Hecht JL, Ip PP, Shaker N, Roma AA, Parkash V, Abubakr H. Endometrial tumors with yolk sac tumor-like morphologic patterns or immunophenotypes: an expanded appraisal. Mod Pathol. 2019 Dec;32(12):1847-1860.
• Li JJX, Ho JYY, Lee CHC, Ng JKM, Lee JHS, Yeung CSY, Ip PPC. Digital image analysis of gland-to-stroma ratio by CD10 objectively differentiates between low-grade endometrioid carcinoma and atypical hyperplasia on endometrial biopsy. Pathology. 2025; 57(4):455-460.
• Chu MM, Liu SS, Tam KF, Ip PP, Cheung AN, Ngan HY. The significance of mismatch repair deficiency in young patients with endometrial cancer. Int J Gynecol Pathol. 2015;34:403-10.

Cytology And Mechanistic Studies

• Shi Z, Artemenko M, Yu W, Zhang M, Yi C, Chen P, Lin S, Bian Z, Lian B, Meng F, Chen J, Roussel T, Li Y, Chan KKL, Ip PPC, Lai HC, To SKY, Liu X, Peng L, Wong AST. Bola-Amphiphilic Dendrimer Enhances Imatinib to Target Metastatic Ovarian Cancer via β-Catenin-HRP2 Signaling Axis. ACS Appl Mater Interfaces. 2025;17(2):2884-2898. 
• Ma J, To SKY, Fung KSW, Wang K, Zhang J, Ngan AHW, Yung S, Chan TM, Wong CCL, Ip PPC, Peng L, Guo HY, Chan CB, Wong AST. P-cadherin mechanoactivates tumor-mesothelium metabolic coupling to promote ovarian cancer metastasis. Cell Rep. 2025;44(1):115096.
• To SKY, Tang MKS, Tong Y, Zhang J, Chan KKL, Ip PPC, Shi J, Wong AST. A selective β-catenin-metadherin/CEACAM1-CCL3 axis mediates metastatic heterogeneity upon tumor-macrophage interaction. Adv Sci (Weinh). 2022;9(16):e2103230.
• Kan T, Wang W, Ip PP, Zhou S, Wong AS, Wang X, Yang M. Single-cell EMT-related transcriptional analysis revealed intra-cluster heterogeneity of tumor cell clusters in epithelial ovarian cancer ascites. Oncogene. 2020;39(21):4227-4240.
• Li SS, Ip C, Tang YH, Tang M, Tong Y, Zhang JW, Hassan A, Mak ASC, Yung S, Chan TM, Ip PP, Lee CL, Chiu P, Lee L, Lai HC, Zeng JZ, Shum H. Wong, AST. Sialyl LewisX-P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flow. Nat Commun. 2019;10:2406.
• Tang MKS, Yue PYK, Ip PP, Huang RL, Lai HC, Cheung ANY, Tse KY, Ngan HYS, Wong AST. Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface. Nat Commun. 2018;9:2270.
• Ng JKM, Cheung BHC, Lee DHY, Li JJX, Ip PPC, Lee JHS, Yeung CSY, Yu MY. Detection rates and factors affecting thereof in endometrial hyperplasia, endometrial carcinoma, and cervical glandular lesions on cervical smear. Cancer Med. 2023;12(17):17581-17591.
  
   

Multi-Disciplinary Collaborations

•  Yu Y, Tse KY, Lee HHY, Chow KL, Tsang HW, Wong RWC, Cheung ETY, Cheuk W, Lee VWK, Chan WK, Wong AST, Loong HHF, Chan KKL, Ngan HYS, Cheung ANY, Ip PPC. Predictive biomarkers and tumor microenvironment in female genital melanomas: a multi-institutional study of 55 cases. Mod Pathol. 2020;33(1):138-152.
• Wong RWC, Ng JHY, Han KC, Leung YP, Shek CM, Cheung KN, Choi CKM, Tse KY, Ip PPC. Cervical carcinomas with serous-like papillary and micropapillary components: illustrating the heterogeneity of primary cervical carcinomas. Mod Pathol. 2021;34(1):207-221.
• Fadare O, Fard EV, Bhargava R, Desouki MM, Hanley KZ, Ip PPC, Li JJX, Lu B, Medeiros F, Ng JHY, Parkash V, Pinto A, Quick CM, Shala SL, Tokuyama M, Turashvili G, Wei CH, Xing D, Zheng W, Soong TR, Howitt BE. The malignant potential of ovarian steroid cell tumors revisited: A multi-institutional clinicopathologic analysis of 115 cases. Am J Surg Pathol 2024;48(5):570-580.
• Devins KM. Young RH, Croce S, Burandt E, Bennett JA, Pesci A, Zannoni GF, Ip PPC, Nielsen GP, Oliva E. Solitary fibrous tumors of the female genital tract: A study of 27 cases emphasizing nonvulvar locations, variant histology, and prognostic factors. Am J Surg Pathol. 2022;46(3):363-375.
• Chan WS, Mo X, Ip PPC, Tse KY. Patient-derived organoid culture in epithelial ovarian cancers-Techniques, applications, and future perspectives. Cancer Med. 2023;12(19):19714-19731.
  
   

 Digital Pathology

•  Levine AB, Peng J, Farnell D, Nursey M, Wang Y, Naso JR, Ren HZ, Farahani H, Chen C, Chiu D, Talhouk A, Sheffield B, Riazy M, Ip PP, Parra-Herran C, Mills A, Singh N, Tessier-Cloutier B, Salisbury T, Lee J, Salcudean T, Jones SJM, Huntsman DJ, Gilks CB, Yip S, Bashashati A. Synthesis of diagnostic quality cancer pathology images. J Pathol. 2020;252(2):178-188. 
• Wong OGW, Ng IFY, Tsun OKL, Pang HH, Ip PP, Cheung ANY. Machine learning interpretation of extended human papillomavirus genotyping by Onclarity in an Asian cervical cancer screening population. J Clin Microbiol. 2019 Nov 22;57(12):e00997-19. 
• Wong OG, Ho MW, Tsun OK, Ng AK, Tsui EY, Chow JN, Ip PP, Cheung AN. An automated quantitative DNA image cytometry system detects abnormal cells in cervical cytology with high sensitivity. Cytopathology. 2018;29:267-274.

INTERNATIONAL PRACTICE GUIDELINES

• Nucci MR, Webster F, Croce S, George S, Howitt BE, Ip PPC, Lee CH, Rabban JT, Soslow RA, van der Griend R, Lax SF, McCluggage WG. Data Set for Reporting of Uterine Malignant and Potentially Malignant Mesenchymal Tumors: Recommendations From the International Collaboration on Cancer Reporting (ICCR). Int J Gynecol Pathol. 2022;41(suppl 1):S44-S63.
• Matias-Guiu X, Selinger CI, Anderson L, Buza N, Ellenson LH, Fadare O, Ganesan R, Ip PPC, Palacios J, Parra-Herran C, Raspollini MR, Soslow RA, Werner HMJ, Lax SF, McCluggage WG. Data Set for the Reporting of Endometrial Cancer: Recommendations From the International Collaboration on Cancer Reporting (ICCR). Int J Gynecol Pathol. 2022;41(suppl 1):S90-S118.
  
• Cho KR, Cooper K, Croce S, Djordevic B, Herrington S, Howitt B, Hui P, Ip P, Koebel M, Lax S, Quade BJ, Shaw P, Vidal A, Yemelyanova A, Clarke B, Hedrick Ellenson L, Longacre TA, Shih IM, McCluggage WG, Malpica A, Oliva E, Parkash V, Matias-Guiu X. International Society of Gynecological Pathologists (ISGyP) Endometrial Cancer Project: Guidelines From the Special Techniques and Ancillary Studies Group. Int J Gynecol Pathol. 2019;38 Suppl 1:S114-S122.