Journal articles, book chapters and other published papers (2008 - 2009)

Scholarly books, monographs and chapter

Cheung A.N.Y., Gestational Trophoblastic Disease, In: Robboy S, Mutter G, Prat J, Bentley RC, Russell P, Anderson MC, Robboy's Pathology of the Female Reproductive Tract. Elsevier Science Health Science Div, 2009, 881-907.

Journal publications

Au C.W.H., Siu K.Y., Liao X., Wong E.S.Y., Ngan H.Y.S., Tam K.F., Chan D.C.W., Chan Q.K.Y. and Cheung A.N.Y., Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome, Cancer Letters. 2009, 281: 151-161.

Au W.S., Lu L., Tam S., Ko K.H., Chow B.K.C., He M.L., Ng S.M., Yeung C.M., Liu C.C., Kung H.F. and Lin M.C., Pluronic L‑81 Ameliorates Diabetic Symptoms In Db/db Mice Through Transcriptional Regulation Of Microsomal Triglyceride Transfer Protein, World Journal of Gasternology. 2009, 15(24): 2987-2994.

Au W.S., Lu L., Yeung C.M., Liu C.C., Wong G.W., Lai L., Kung H.F. and Lin M.C., The HNF-1a Binding Element within the Promoter of MTP Gene is Crucial for MTP Basal Expression and Insulin Responsiveness, Journal of Molecular Endocrinology. 2008, 41: 229-238.

Au W.Y., Wong K.Y., Wan T.S.K., So J.C.C., Srivastava G. and Liang R.H.S., A unique case of B cell lymphoma relapsing as CD4/CD56 blastic neoplasm, Leuk Lymphoma . 2009, 50(6): 932-6.

Au W.Y., Ha S.Y., Wan T.S.K., So J.C.C. and Wong K.F., A unique case of familial leukaemia: maternal puerperal leukaemia followed by infantile leukaemia with monosomy 7, Br J Haematol. 2008, 143(3): 445-6.

Au W.Y., Tam S., Fong B.M. and Kwong Y.L., Determinants of cerebrospinal fluid arsenic concentration in patients with acute promyelocytic leukemia on oral arsenic trioxide therapy, Blood. 2008, 112(9): 3587-3590.

Au W.Y., So J.C.C., Ma E.S.K. and Lie A.K.W., Glucose-6-phosphate-dehydrogenase deficiency and haematopoietic stem cell transplantation in Chinese patients, Hong Kong Med J . 2009, 15(3 Suppl 3): 35-8.

Au W.Y., Wong K.Y., Leung R.Y.Y. and Tong A.C.K., Isolated gingival relapse of acute lymphoblastic leukemia after transplantation, Journal of Oral Pathology & Medicine. 2008, 37(4): 249-251.

Au W.Y., Tam S., Fong B.M. and Kwong Y.L., Oral arsenic treatment of leukemia and the risk of porphyria, Leukaemia Research . 2009, 33(4): 598-600.

Au W.Y., Tse J., So J.C.C., Wan T.S.K. and Young K., Unexpected glucose-6-phosphate dehydrogenase deficiency, Br J Haematol. 2008, [Epub ahead of print].

Chan D.W., Chan P.C.Y., Lee M.F. and Ng I.O.L., Genetic and epigenetic inactivation of T-cadherin in human hepatocellular carcinoma cells, International Journal of Cancer. wiley, 2008, 123: 1043-1052.

Chan D.W., Yu Y.M., Chiu P.M., Yao K.M., Liu V.W.S., Cheung A.N.Y. and Ngan H.Y.S., Over-expression of FOXM1 transcription factor is associated with cervical cancer progression and pathogenesis, Journal of Pathology. 2008, 215 (3): 245-252.

Chan G.S.W., Tsoi H.W., Wong S.S.Y., Li C.L., Tse H., Uni K., Yuen K.Y. and Chan K.W., BK virus nephropathy due to KOM-3 strain., American journal of kidney diseases. 2008, 54(1): 122-126.

Chan H.Y., Siu K.Y., Zhang H., Wong E.S.Y., Ngan H.Y.S., Chan K.Y.Q. and Cheung A.N.Y., Activated Stat3 expression in gestational trophoblastic disease: correlation with clinicopathological parameters and apoptotic indices, Histopathology. 2008, 53(2): 139-146.

Chan K.Y.Q., Ngan H.Y.S., Ip P.P.C., Liu V.W.S., Xue W. and Cheung A.N.Y., Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis: a differential expression and functional analysis, Carcinogenesis. Oxford Journals, 2009, 30: 114-121.

Chan L.C., Factors affecting the quality of problem-based learning in a hybrid medical curriculum, The Kaohsiung Journal of Medical Sciences. 2009, 32(5): 254-257.

Chan L.K., Ko F.C.F., Ng I.O.L. and Yam J.W.P., Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function, PLoS One. 2009, 4: e5572.

Chan V.N.Y., Khoo U.S., Wong M.S., Lau K.M.K., Suen D.T.K., Li G.K.H., Kwong A. and Chan T.K., Localization of hRad9 in breast cancer, BMC Cancer. 2008, 8: 196.

Chan Y.K., Liu W., Long J.R., Yip S.P., Chan S.Y., Shu X.O., Chua D.T.T., Cheung A.N.Y., Ching C.Y.J., Cai H., Au G.K.H., Chan M., Foo W., Ngan H.Y.S., Gao Y.T., Ngan E.S.W., Garcia-Barcelo M.M., Zheng W. and Khoo U.S., Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women., J Med Genet. 2009, 46: 32-39.

Chan Y.K., Liu W., Long J.R., Yip S.P., Chan S.Y., Shu X.O., Chua D.T.T., Cheung A.N.Y., Ching J.C.Y., Cai H., Au G.K.H., Chan M., Foo W., Ngan H.Y.S., Gao Y.T., Ngan E.S.W., Garcia-Barcelo M.M., Zheng W.E.I. and Khoo U.S., Functional polymorphisms in the promoter of BRCA1 influences transcription and are associated with decreased risk for breast cancer in Chinese women, Journal of Medical Genetics. 2009, 46(1): 32-39.

Chang Y.K., Yang W., Zhao M., Mok C.C., Chan T.M., Wong R.M.Y., Lee K.W., Mok T.M.Y., Wong S.N., Ng I.O.L., Lee T.L., Ho M.H.K., Lee P.P.W., Wong W.H.S., Lau C.S., Sham P.C. and Lau Y.L., Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese, Genes & Immunity (Advance online publication). 2009, 10: 414-420.

Chen L., Hu L., Chan H.M., Tsao G.S.W., Huo K.K., Fu L., Ma S.K.Y., Zheng B. and Guan X.Y., Chromodomain helicase/adenosine triphosphatase DNA binding protein 1-like (CHD1l) gene suppresses the nucleus-to-mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survival., Hepatology. 2009, 50: 122-129.

Cheung A.N.Y., Zhang H., Xue W. and Siu K.Y., Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives, Future Oncology. 2009, 5(2): 217-231.

Chim J.C.S., Loong F., Ng W.K. and Kwong Y.L., Use of fludarabine-containing chemotherapeutic regimen results in durable complete remission of subcutaneous panniculitis-like T-cell lymphoma, American Journal of Clinical Dermatology. 2008, 9(6): 396-8.

Chow C.P., Ho M.H.K., Chan G.C.F., Cheung A.N.Y. and Ha S.Y., Congenital Rosai-Dorfman disease presenting with anemia, thrombocytopenia, and hepatomegaly, Pediatric Blood & Cancer. 2009, 52(3): 415-417.

Chua D.T.T., Wei W.I., Wong M.P., Sham J.S.T., Nicholls J.M. and Au G.K.H., Phase II study of gefitinib for the treatment of recurrent and metastatic nasopharyngeal carcinoma, Head & Neck. 2008, 30(7): 863-7.

Chung H.Y., Trendell-Smith N.J., Yeung C.K. and Mok T.M.Y., Dego’s disease – a rare condition simulating rheumatic diseases [Epub Mar 20], Clinical Rheumatology. 2009, 28(7): 861-863.

Cui Y., Ying Y., van Hasselt A., Ng K.M., Yu J., Zhang Q., Jin J., Liu D., Rhim J.S., Rha S.Y., Loyo M., Chan A.T., Srivastava G., Tsao G.S.W., Sellar G.C., Sung J.J., Sidransky D. and Tao Q., OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation, PLoS ONE. 2008, 3(8): e2990.

Dai Y., Qiao L., Chan K.W., Yang M., Ye J., Ma J., Zou B., Gu Q., Wang J., Pang R.W.C., Lan H.Y. and Wong B.C.Y., Peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of Embelin on colon carcinogenesis, Cancer Research. 2009, 69 (11): 4776–83.

Deng W., Tsao G.S.W., Kwok K.Y., Wong E.S.Y., Huang X.R., Liu S., Tsang C.M., Ngan H.Y.S., Cheung A.N.Y., Lan H.Y., Guan X.Y. and Cheung A., Transforming growth factor b1 promotes chromosomal instability in human papillomavirus 16 E6E7-infected cervical epithelial cells, Cancer Research. 2008, 68: 7200-7209.

Dong G., Chanudet E., Hamoudi R.A., Chen W.Y.W., Chuang S.S., Ye H., Liu H., Gao Z., Srivastava G. and Du M.Q., Genomic Profiles of Gastrointestinal Diffuse Large B-cell Lymphoma, The Journal of Pathology. 2009, 219: S5.

Fan P.Y.S., Lui P.C., Tam K.Y., Hung K.N., Ng H.K. and Leung S.Y., A 33-year-old Chinese woman with a left frontal tumor, Brain Pathol.. 2009, 19(2): 337-40.

Fu K., Weisenburger D.D., Choi W.L., Perry K.D., Smith L.M., Shi X., Hans C.P., Greiner T.C., Bierman P.J., Bociek R.G., Armitage J.O., Chan W.C. and Vose J.M., Addition Of Rituximab To Standard Chemotherapy Improves The Survival Of Both The Germinal Center B-cell-like And Non-germinal Center B-cell-like Subtypes Of Diffuse Large B-cell Lymphoma, Journal Of Clinical Oncology . 2008, 26: 4587-4594.

Fu L., Gao Z., Zhang X., Tsang Y.H., Goh H.K., Geng H., Shimizu N., Tsuchiyama J., Srivastava G. and Tao Q., Frequent concomitant epigenetic silencing of the stress-responsive tumor suppressor gene CADM1, and its interacting partner DAL-1 in nasal NK/T-cell lymphoma, Int J Cancer. 2008, 124(7): 1572-1578.

Gibney G.T., Panhuysen C.I.M., So J.C.C., Ma E.S.K., Ha S.Y., Li C.K., Lee A.C.W., Li C.K., Yuen H.L., Lau Y.L., Johnson D.M., Farrell J.J., Bisbee A.B., Farrer L.A., Steinberg M.H., Chan L.C. and Chui D.H.K., Variation and heritability of Hb F and F-cells among b-thalassemia heterozygotes in Hong Kong, American Journal of Hematology. 2008, 83(6): 458-464.

Ho P.L., Wong M.P., Lai E.L.Y., Chan K.H. and Chiu S.S.S., DNA typing of cytological samples for retrospective identification of an early case of Panton-Valentine leucocidin-positive, community-associated methicillin-resistant Staphylococcus aureus pneumonia, J Clin Microbiol. 2008, 46: 2457-2458.

Hwang Y.Y., Tse E.W.C., So J.C.C., Wan T.S.K. and Kwong Y.L., Persistent neutropenia in chronic myelogenous leukemia in chronic phase treated with imatinib mesylate, American Journal of Hematology. 2009, 84(5): 302-5.

Hwang Y.Y., Wong K.Y., Leung R.Y.Y., Wong S.H., Chan S.C., Srivastava G. and Au W.Y., Post-rituximab Burkitt transformation of PTLD: loss of CD20 expression accompanied by a switch in light-chain expression, Ann Hematol. 2009, [Epub ahead of print].

Hwang Y.Y., Leung A.Y.H., Ng I.O.L., Chan G.S.W., Chan K.W., Tse E.W.C. and Kwong Y.L., Protein-Losing Enteropathy Due to T-Cell Large Granular Lymphocyte Leukemia, Journal of Clinical Oncology. 2009, 27(12): 2097-8.

Iqbal J., Kucuk C., Deleeuw R.J., Srivastava G., Tam W., Geng H., Klinkebiel D., Christman J.K., Patel K., Cao K., Shen L., Dybkaer K., Tsui I.F., Ali H., Shimizu N., Au W.Y., Lam W.L. and Chan W.C., Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies, Leukemia. 2009, Epub 2009 Feb 5.

Jacobs C.L., Lagoo A.S., Dash R.C., Raji A., Evens A.M., Winter J.N., Gordon L.I., Kahl B.S., Czader M., Srivastava G., Mann K.P., Gill J., Rizzieri D. and Dave S., MicroRNAs Distinguish Burkitt Lymphoma from the Molecular Subsets of Diffuse Large B Cell Lymphoma, Blood. 2008, 112(11): 1151.

Kucuk C., Iqbal J., Deleeuw R.J., Srivastava G., Tam W., Klinkebiel D., Christman J.K., Dybkaer K., Au W.Y., Lam W.L. and Chan W.C., Genomic Analyses Reveal Global Functional Alterations That Promote Tumor Growth and Novel Tumor Suppressor Genes in Natural Killer-Cell Malignancies, Blood. 2008, 112(11): 1298.

Kwan T.T.C., Chan K.K.L., Yip M.W., Tam K.F., Cheung A.N.Y., Lo S.S.T., Lee P.W.H. and Ngan H.Y.S., Acceptability of human papillomavirus vaccination among Chinese women: concerns and implications, BJOG An International Journal of Obstetrics and Gynaecology. 2009, 116 (4): 501-510.

Lam B., Lam S.Y., Wong M.P., Ooi C.G.C., Fong D.Y., Lam C.L., Lai A.Y., Tam C.M., Pang C.B.Y., Ip M.S.M. and Lam W.K., Sputum Cytology Examination Followed By Autofluorescence Bronchoscopy: A Practical Way Of Identifying Early Stage Lung Cancer In Central Airway, Lung Cancer. 2009, 64: 289-294.

Lam C.W., DNA-based Diagnosis of Cardiac Arrhythmia in Paediatric Patients, Journal of the Hong Kong College of Cardiology. 2009, 17(Supp 1): 9.

Lam C.W., Lan L.C.L., Che C.M., Tam S., Wong S.S.Y., Chen Y., Jin J., Tao S.H., Tang X.M., Yuen K.Y. and Tam P.K.H., Diagnosis and spectrum of melamine-related renal disease: plausible mechanism of stone formation in humans, Clinica Chimica Acta. 2009, 402: 150-155.

Lam C.W., High Prevalence Rate of Wilson Disease in Hong Kong: 1 in 5400, Brainchild. 2009, 10(1).

Lam M.F., Leung J.C.K., Lam C.W., Tse K.C., Lo W.K., Lui S.L., Chan D.T.M., Tam S. and Lai K.N., Procalcitonin fails to differentiate inflammatory status or predict long-term outcomes in peritoneal dialysis-associated peritonitis, Peritoneal Dialysis International. 2008, 28: 377-84.

Lam Q.L.K., Ko K.H., Zheng B.J. and Lu L., Local BAFF gene silencing suppresses Th17 cell generation and ameliorates autoimmune arthritis, Proceedings of the National Academy of Sciences. 2008, 105(39): 14993-14998.

Lam Q.L.K., Ko K.H., Zheng B. and Lu L., Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis, Proc Natl Acad Sci USA. 2008, 105(39): 14993-14998.

Lamb S.S., Khong P.L., Chan G.S.W. and Kwong Y.L., DIAGNOSIS IN ONCOLOGY Immunoglobulin M Amyloidosis, Journal of Clinical Oncology. 2009, 27(11): 1915-1916.

Lamb S.S., Khong P.L., Chan G.S.W. and Kwong Y.L., Immunoglobulin M amyloidosis, Journal of Clinical Oncology. 2009, 27: 1915-1916.

Lau E.Y.F., So S.Y., Chan E.Y.T., Kwok J.S.Y., Ma J.T.C. and Kung A.W.C., Methimazole-induced antineutrophil cytoplasmic antibody-associated diffuse alveolar haemorrhage in a Chinese woman with Graves' disease, Hong Kong Med J.. 2009, 15(3): 209-12.

Lee C.K.F., Tam Y.T., Zuo Y., Cheong A.W.Y., Pang R.T.K., Lee P.Y., Shum K.Y., Tam P.C., Cheung A.N.Y., Yang Z.M., Yeung W.S.B. and Luk J.M.C., Characterization of an acrosome protein VAD1.2/AEP2 which is differentially expressed in spermatogenesis, Molecular Human Reproduction. 2008, 14(8): 465-474.

Lee K.Y., Geng H., Ng K.M., Yu J., van Hasselt A., Cao Y., Zeng Y.X., Wong A.H., Wang X., Ying J., Srivastava G., Lung M.L., Wang L.D., Kwok T.T., Levi B.Z., Chan A.T., Sung J.J. and Tao Q., Epigenetic disruption of interferon-gamma response through silencing the tumor suppressor interferon regulatory factor 8 in nasopharyngeal, esophageal and multiple other carcinomas, Oncogene. 2008, 27(39): 5267-5276.

Lee M.F., Wong C.M. and Ng I.O.L., Hepatitis B virus-associated multistep hepatocarcinogenesis: a stepwise increase in allelic alterations, In: Cancer Research, 2008, 68 (14): 5988-5996.

Lee M.Y., Cheung C.Y., Nicholls J.M., Hui P.Y., Leung C.Y.H., Uiprasertkul M., Tipoe G.L., Lau Y.L., Poon L.L.M., Ip N.Y., Guan Y. and Peiris J.S.M., Hyperinduction of Cyclooxygenase-2-Mediated Proinflammatory Cascade: A Mechanism for the Pathogenesis of Avian Influenza H5N1 Infection, The Journal of Infectious Diseases. 2008, 198(4): 525-35.

Leung G.M., Woo P.S., Cowling B.J., Tsang C.S.H., Cheung A.N.Y., Ngan H.Y.S., Galbraith K.P. and Lam T.H., Who receives, benefits from and is harmed by cervical and breast cancer screening among Hong Kong Chinese?, Journal of Public Health. 2008, 30(3): 282-292.

Leung L.H., Tam I.Y., Tin P.C., Chua D.T.T., Sihoe A.D.L., Cheung L.C., Ho J.C.M., Chung L.P. and Wong M.P., Src Promotes Survival and Invasion of Lung Cancers with Epidermal Growth Factor Receptor Abnormalities and Is a Potential Candidate for Molecular-Targeted Therapy., Molecular Cancer Research. 2009, 7(6): 923-32.

Li A.S., Siu M.K., Zhang H., Wong E.S., Chan K.Y., Ngan H.Y.S. and Cheung A.N.Y., Hypermethylation of SOX2 gene in hydatidiform mole and choriocarcinoma, Reproductive Science. PubMed PMID:18836133, 2008, 15(7): 735-744.

Li O.T.W., Chan M.C.W., Leung C.S.W., Chan W.Y., Guan Y., Nicholls J.M. and Poon L.L.M., Full factorial analysis of Mammalian and avian influenza polymerase subunits suggests a role of an efficient polymerase for virus adaptation., In: Li OT, Chan MC, Leung CS, Chan RW, Guan Y, Nicholls JM, Poon LL., PLoS ONE. 2009, 21;4(5): e5658.

Liao X., Siu K.Y., Au W.H., Chan K.Y.Q., Chan H.Y., Wong E.S.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through β-catenin., Modern Pathol.. 2009, 22: 839-847.

Liao X., Siu K.Y., Au W.H., Wong E.S.Y., Chan H.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation., Carcinogenesis. 2009, 30: 131-140.

Liao X., Siu K.Y., Wong E.S.Y., Ngan H.Y.S., Chan K.Y.Q., Li A.S.M., Khoo U.S. and Cheung A.N.Y., Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis, Int J Cancer. 2008, 123(2): 296-302.

Liao X., Siu M.K., Au C.W.D., Chan Q.K., Chan H.Y., Wong E.S., IP P.P., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through beta-catenin, Mod Pathol. 2009 Jun;22(6):839-47. Epub 2009 Mar 27. 2009, 839-47.

Ligtenberg M.J., Kuiper R.P., Chan T.L., Goossens M., Hebeda K.M., Voorendt M., Lee T.Y.H., Bodmer D., Hoenselaar E., Hendriks-Cornelissen S.J., Tsui W.Y., Kong C.K., Brunner H.G., van Kessel A.G., Yuen S.T., van Krieken J.H., Leung S.Y. and Hoogerbrugge N., Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1, Nat Genet. 2009, 41(1): 112-7.

Ling M.T., Chiu Y.T., Lee K.W., Leung S.C., Fung K.L., Wang X., Wong K.F. and Wong Y.C., Id-1 induces proteasome-dependent degradation of the HBX protein, Journal of molecular Biology. 2008, 382: 34-43.

Liu X., Wu W.K., Yu L., Sung J.J., Srivastava G., Zhang S.T. and Cho C.H., Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathway, J Cell Biochem. 2008, 105(1): 53-60.

Lo C.K., Lam Q.L.K., Sun L., Wang S., Ko K.H., Xu H., Wu C.Y., Zheng B. and Lu L., Natural killer cell degeneration exacerbates experimental arthritis in mice via enhanced interleukin-17 production, Arthritis and Rheumatism. 2008, 58(9): 2700-2711.

Lui S.L., Tsang R.C.W., Chan K.W., Zhang Q., Tam S., Yung S.S.Y. and Chan D.T.M., Rapamycin attenuates the severity of murine adriamycin nephropathy [Epub 27Aug 2008], American Journal of Nephropathy. 2008, 29: 342-352.

Ma S.K.Y., Chan K.W., Lee K.W., Tang K.H., Wo Y.H., Zheng B. and Guan X.Y., Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations, Molecular Cancer Research. 2008, 6: 1146-1153.

Ma S.K.Y., Chan Y.P., Woolcock B., Hu L., Wong K.Y., Ling M.T., Bainbridge T., Webber D., Chan H.M., Guan X.Y., Lam W., Vielkind J. and Chan K.W., DNA fingerprinting tags novel altered chromosomal regions and identifies the involvement of SOX5 in the progression of prostate cancer, International Journal of Cancer. 2009, 124: 2323-2332.

Ma S.K.Y., Chan K.W. and Guan X.Y., In search of liver cancer stem cells, Stem Cell Reviews. 2008, 4: 179-192.

Naushad H., Choi W.L., Page C.J., Sanger W.G., Weisenburger D.D. and Aoun P., Mantle Cell Lymphoma with Flow Cytometric Evidence of Clonal Plasmacytic Differentiation: A Case Report, Cytometry: Part B -- Clinical Cytometry. Wiley-Blackwell, 2009, 76: 218-224.

Ngan E.S.W., Lang B.H.H., Liu T., Shum K.Y., So M.T., Lau K.C., Leon Y.Y., Cherny S.S., Tsai S.Y., Lo C.Y., Khoo U.S., Tam P.K.H. and Garcia-Barcelo M.M., A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma, Journal of the National Cancer Institute. 2009, 101(3): 162-175.

Nicholls J.M., Peiris J.S.M. and Guan Y., Sialic acid and receptor expression on the respiratory tract in normal subjects and H5N1 and non-avian influenza patients, Hong Kong Medical Journal. 2009, 15(3 Suppl 4): 16-20.

Pak K.C., Lam A.K.Y., Law S.Y.K. and Tang J.C.O., The inhibitory effect of Gleditsia sinensis on cyclooxygenase-2 expression in human esophageal squamous cell carcinoma, International Journal of Molecular Medicine. 2009, 23(1): 121-129.

Peiris J.S.M., Poon L.L.M., Nicholls J.M. and Guan Y., The role of influenza virus gene constellation and viral morphology on cytokine induction, pathogenesis, and viral virulence, Hong Kong Medical Journal. 2009, 15(3 Suppl 4): 21-3.

Pon Y.L., Zhou G., Cheung A.N.Y., Ngan H.Y.S. and Wong A.S.T., p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells., Cancer Research. PubMed PMID:18701475, 2008, 68(16): 6524-6532.

Poon L.L.M., Leung C.Y.H., Nicholls J.M., Lichy J.H., Yamamoto M., Waldmann T.A., Peiris J.S.M. and Perera L.P., Vaccinia virus-based multivalent H5N1 avian influenza vaccines adjuvanted with IL-15 confer sterile cross-clade protection in mice, The Jounal of Immunology. 2009, 182(5): 3063-71.

Schetter A.J., Leung S.Y., Sohn J.J., Zanetti K.A., Bowman E.D., Yanaihara N., Yuen S.T., Chan T.L., Kwong D.L.W., Au G.K., Liu C.G., Calin G.A., Croce C.M. and Harris C.C., MicroRNA Expression Profiles Associated With Prognosis And Therapeutic Outcome In Colon Adenocarcinoma., Journal of the American Medical Association. 2008, 299: 425-36.

Sedgewick A.E., Timofeev N., Sebastiani P., So J.C.C., Ma E.S.K., Chan L.C., Fucharoen G., Fucharoen S., Barbosa C.G., Vardarajan B.N., Farrer L.A., Baldwin C.T., Steinberg M.H. and Chui D.H.K., BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies, Blood Cells Mol Dis. 2008, 41(3): 255-8.

Shen L., Au W.Y., Wong K.Y., Shimizu N., Tsuchiyama J., Kwong Y.L., Liang R.H.S. and Srivastava G., Cell death by bortezomib-induced mitotic catastrophe in natural killer lymphoma cells, Molecular Cancer Therapeutics. 2008, 7(12): 3807-15.

Siu K.Y., Wong E.S.Y., Chan H.Y., Ngan H.Y.S., Chan Y.K. and Cheung A.N.Y., Overexpression of NANOG in Gestational Trophoblastic Diseases. Effect on Apoptosis, Cell Invasion, and Clinical Outcome, Am J Pathol. 2008, [Epub ahead of print].

Siu Y.L., Teoh K.T., Lo J.C.Y., Chan C.M., Kien F.S., Escriou N., Tsao G.S.W., Nicholls J.M., Altmeyer R.M., Peiris J.S.M., Bruzzone R. and Nal-Rogier B.T.M., The M, E and N structural proteins of the SARS coronavirus are required for efficient assembly, trafficking and release of virus-like particles., Journal of Virology. 2008.

Siu Y.L., Teoh K.T., Lo J.C.Y., Chan C.M., Kien F.S., Escriou N., Tsao G.S.W., Nicholls J.M., Altmeyer R.M., Peiris J.S.M., Bruzzone R. and Nal-Rogier B.T.M., The M, E, And N Structural Proteins Of The Severe Acute Respiratory Syndrome Coronavirus Are Required For Efficient Assembly, Trafficking, And Release Of Virus-like Particles., Journal of Virology. 2008, 82(22): 11318-30.

So J.C.C., Wan T.S.K., Ma E.S.K. and Chan L.C., An unbalanced translocation, der(17)t(1;17)(p13;p11.2), leads to heterozygous loss of TP53 and is associated with clinical evolution in myelodysplastic syndrome, Br J Biomed Sci. 2008, 65(1): 36-38.

So J.C.C., Song Y., Tsang S.T.Y., Tang L.F., Chan A.Y.W., Ma E.S.K. and Chan L.C., The HBS1L-MYB intergenic region on chromosome 6q23 is a quantitative trait locus controlling fetal haemoglobin level in carries of β-thalassaemia, J Med Gen. 2008, 45(11): 745-51.

Sun Q., So J.C.C., Yip S.F., Wan T.S.K., Ma E.S.K. and Chan L.C., Functional alterations of Lin-CD34+CD38+ cells in chronic myelomonocytic leukemia and on progression to acute leukemia, Leuk Res. 2008, 32(9): 1374-1381.

Sung J.J., Lau J.Y., Young G.P., Sano Y., Chiu H.M., Byeon J.S., Yeoh K.G., Goh K.L., Sollano J., Rerknimitr R., Matsuda T., Wu K.C., Ng S., Leung S.Y., Makharia G., Chong V.H., Ho K.Y., Brooks D., Lieberman D.A. and Chan F.K., Asia Pacific consensus recommendations for colorectal cancer screening, Gut. 2008, 57(8): 1166-76.

Sze M.F., Ching Y.P., Jin D. and Ng I.O.L., Role of a novel splice variant of mitotic arrest deficient 1 (MAD1), MAD1beta, in mitotic checkpoint control in liver cancer, In: American Association for Cancer Research, Cancer Research. 2008, 68: 9194-9201.

Tam C.W., Chan K.W., Liu V.W.S., Pang B., Yao K.M. and Shiu S.Y.W., Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance, Journal of Pineal Research. 2008, 45: 403-412.

Tang H.W., Ng K.M., Chui S.Y., Che C.M., Lam C.W., Yuen K.Y., Siu T.S., Lan L.C.L. and Chen X.Y., Analysis of Melamine Cyanurate in Urine Using Matrix-Assisted Laser Desorption / Ionization Mass Spectrometry , Analytical Chemistry. 2009, 81: 3676-3682.

Tay S.K., Ngan H.Y.S., Chu T.Y., Cheung A.N.Y. and Tay E.H., Epidemiology of human papillomavirus infection and cervical cancer and future perspectives in Hong Kong, Singapore and Taiwan, Vaccine. PubMed PMID:18945415, 2008, 19 (Suppl 12): M60-70.

Tse E.W.C., Leung R.Y.Y., Khong P.L., Lau W.H. and Kwong Y.L., Non-nasal natural killer cell lymphoma: not non-nasal after all, Annals of Hetmatology. 2009, 88: 185-187.

Tse H.F., Liao S., Siu D.C.W., Liu Y., Nicholls J.M., Leung G., Ormsby T., Feld G.K. and Lau C.P., Determinants of lesion dimensions during transcatheter microwave ablation, Pacing Clin Electrophysiol. . 2009, 32(2): 201-8.

Tse K.Y., Liu V.W.S., Chan D.W., Chiu P.M., Tam K.F., Chan K.K.L., Liao X., Cheung A.N.Y. and Ngan H.Y.S., Epigenetic alteration of the metallothionein 1E gene in human endometrial carcinomas, Tumor Biology. 2009, 30: 93-99.

Tung K.K., Wong C.M., Yau T.O., Lee M.F., Ching Y.P. and Ng I.O.L., HAI-2 is epigenetically downregulated in human hepatocellular carcinoma, and its Kunitz domain type 1 is critical for anti-invasive functions. , International Journal of Cancer. 2009, 124: 1811.

Wang Y., Li J., Cui Y., Li T., Ng K.M., Geng H., Li H., Shu X.S., Li H., Liu W., Luo B., Zhang Q., Mok T.S., Zheng W., Qiu X., Srivastava G., Yu J., Sung J.J., Chan A.T., Ma D., Tao Q. and Han W., CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis, Cancer Res. 2009, 69(12): 5194-201.

Wong C.C.L., Wong C.M., Ko F.C.F., Chan L.K., Ching Y.P., Yam J.W.P. and Ng I.O.L., Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma, PLoS One. 2008, 3: e2779.

Wong C.L., Wong C.M., Tung K.K., Man K. and Ng I.O.L., Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion., Hepatology. 2009, 49 (5): 1583-1594.

Wong C.Y., Qiuwaxi J., Chen H., Li S.W., Chan H.T., Tam S., Shu X.O., Lau C.P., Kwong Y.L. and Tse H.F., Daily intake of thiamine correlates with the circulating level of endothelial progenitor cells and the endothelial function in patients with type II diabetes, Molecular Nutrition & Food Research. online, 2008, 52 (12): 1421 - 1427.

Wong M.K.Y., Wong M.P., Lam C.L., Sihoe A.D.L., Cheng L.C., Lam B., Ip M.S.M., Nakajima T., Yasufuku K., Lam W.K. and Ho J.C.M., Endobronchial ultrasound for diagnosis of synchronous primary lung cancers, Lung Cancer. 2009, 63: 154-157.

Wong V.C.L., Chan P.L., Bernabeu C., Law S.Y.K., Wang L.D., Li J.L., Tsao G.S.W., Srivastava G. and Lung M.L., Identification of an invasion and tumor-suppressing gene, Endoglin (ENG), silenced by both epigenetic inactivation and allelic loss in esophageal squamous cell carcinoma, International Journal of Cancer. 2008, 123(12): 2816-2823.

Wong W.S., Leung L.H., So K.T., Tam Y.S.I., Sihoe A.D.L., Cheng L.C., Ho K.K., Au J.S., Chung L.P. and Wong M.P., The Eml4-alk Fusion Gene Is Involved In Various Histologic Types Of Lung Cancers From Nonsmokers With Wild-type Egfr And Kras, Cancer. 2009, 115: 1723-1733.

Wu P., Wu J., Liu S., Han X., Lu J., Shi Y., Wang J., Lu L. and Cao X., TLR9/TLR7-triggered downregulation of BDCA2 expression on human plasmacytoid dendritic cells from healthy individuals and lupus patients., In: Wu P, J Wu, S Liu; X Han; J Lu, , Clinical Immunology. 2008, 129(1): 40-8.

Wu Y., Chan W.S., Nicholls J.M., Liao S., Tse H.F. and Wu E.X., MR study of the effect of infarct size and location on left ventricular functional and microstructural alterations in porcine models, Journal of Magnetic Resonance Imaging. 2009, 29(2): 305-12.

Xu Z., Yao T.J., Lee P.Y., Ng I.O.L., Chan Y.T., Zender L., Lowe S.W., Poon R.T.P. and Luk J.M.C., Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma, Cancer. 2009, 115(19): 4576-4585.

Yam J.W.P., Tse Y.T. and Ng I.O.L., Role and significance of focal adhesion proteins in hepatocellular carcinoma, J Gastroenterol Hepatol. 2009, 24: 520-530.

Yang W., Zhao M., Hirankarn N., Lau W.C.S., Mok C.C., Chan D.T.M., Wong R.W.S., Lee G.K.W., Mok T.M.Y., Wong S.N., Avihingsanon Y., Ng I.O.L., Lee T.L., Ho M.H.K., Lee P.P.W., Wong W.H.S., Sham P.C. and Lau Y.L., ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai, Human Molecular Genetics. 2009, 18(11): 2063-2070.

Yau T.O., Chan C.F., Lam S.G.S., Cheung O.F., Ching Y.P., Jin D., Sham M.H. and Ng I.O.L., Hepatocyte-specific activation of NF-KB does not aggravate chemical hepatocarcinogenesis in transgenic mice, The Journal of Pathology. 2008, 217: 353-361.

Yeung C.K., Trendell-Smith N.J., Mak H.K.F., Lam C.C.K. and Kwong Y.L., Cutaneous intravascular large B-cell lymphoma: Asian variant or not? , Clinical and Experimental Dermatology (2009, in press).. 2009.

Yip P.S.F., Wong P.W.C., Cheung Y.T., Chan K.S. and Beh S.L., An empirical study of characteristics and types of homicide-suicides in Hong Kong, 1989-2005, Journal of Affective Disorders. 2009, 112(1-3): 184-192.

Yuen H.F., Chan Y.P., Law S.Y.K., Srivastava G., E1-tanani M., Mak T.W. and Chan K.W., DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma, Cancer Epidemiology, Biomarkers & Prevention. 2008, 17(12): 3593-3602.

Yuen H.F., Kwok W.K., Chan K.K., Chua C.W., Chan Y.P., Chu Y.Y., Wong Y.C., Wang X. and Chan K.W., TWIST modulates prostate cancer cell-mediated bone cell activity and is upregulated by osteogenic induction, Carcinogenesis. 2008, 29(8): 1509-18.

Yuen P.W., Ho C.M., Chow T.L., Tang L.C., Cheung W.Y., Ng W.M., Wei W.I., Kong C.K., Book K.S., Yuen W.C., Lam A.K., Yuen N.W., Trendell-Smith N.J., Chan Y.W., Wong B.Y.H., Li G.K.H., Ho A.C.W., Ho W.K., Wong S.Y. and Yao T.J., Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma, Head and Neck. 2009, 31: 765-772.

Yuen R.M.F., Wong D.K.H., Fung J.Y.Y., Ip P.P.C., But D., Hung I.F.N., Lau K., Yuen J.C.H. and Lai C.L., HBsAg Seroclearance in Chronic Hepatitis B in Asian Patients: Replicative Level and Risk of Hepatocellular Carcinoma, Gastroenterology. 2008, 135(4): 1192-9.

Yung S.S.Y., Zhang Q., Zhang C., Chan K.W., Lui S.L. and Chan D.T.M., Anti-DNA antibody induction of protein kinase C phosphorylation and fibronectin synthesis in human and murine lupus and the effect of mycophenolic acid, Arthritis Rheumatism. 2009, 60: 2071-2082.

Zhang H., Xue W.C., Siu K.Y., Liao X., Ngan H.Y.S. and Cheung A.N.Y., P63 Expression in Gestational Trophoblastic Disease: Correlation With Proliferation and Apoptotic Dynamics., Int. J. Gynecol. Pathol. . 2009, 28: 172-178.

Zhou J., Chen D., Poon K.M., Zeng Y., Ng F., Lu L., Huang J., Yuen K.Y. and Zheng B., A comprehensive study of interferon-γ receptor 1 gene polymorphisms and susceptibility to chronic hepatitis B virus infection. , Immunogenetics. 2009, 61(6): 423-430.

Zhou J., Smith D.K., Lu L., Poon K.M., Ng F., Chen D., Huang J., Yuen K.Y. and Zheng B., A non-synonymous single nucleotide polymorphism in IFNAR1 affects susceptibility to chronic hepatitis B virus infection, J Viral Hepat. 2009, 16(1): 45-52.

Zhou J., Huang J., Poon V.K.M., Chen D.Q., Chan C.C.S., Ng F., Guan X.Y., Watt R.M., Lu L., Yuen K.Y. and Zheng B., Functional dissection of an IFN-α/β receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection , Journal of Hepatology. 2009, V51(2): 322-32.

Zhu J.Y., Pfuhl T., Motsch N., Barth S., Nicholls J.M., Grasser F. and Meister G., Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas, Journal of Virology. 2009, 83(7): 3333-41.

van Haaften G., Dalgliesh G.L., Davies H., Chen L., Bignell G., Greenman C., Edkins S., Hardy C., O'Meara S., Teague J., Butler A., Hinton J., Latimer C., Andrews J., Barthorpe S., Beare D., Buck G., Campbell P.J., Cole J., Forbes S., Jia M., Jones D., Kok C.Y., Leroy C., Lin M.L., McBride D.J., Maddison M., Maquire S., McLay K., Menzies A., Mironenko T., Mulderrig L., Mudie L., Pleasance E., Shepherd R., Smith R., Stebbings L., Stephens P., Tang G., Tarpey P.S., Turner R., Turrell K., Varian J., West S., Widaa S., Wray P., Collins V.P., Ichimura K., Law S.Y.K., Wong J., Yuen S.T., Leung S.Y., Tonon G., DePinho R.A., Tai Y.T., Anderson K.C., Kahnoski R.J., Massie A., Khoo S.K., Teh B.T., Stratton M.R. and Futreal P.A., Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer, Nature Genetics. 2009, 41(5): 521-523.

All other outputs

Lam C.W., The development of a rapid polymerase chain reaction (PCR)-based assay for detection of genetic variation in genes of iron and methylation metabolism to assist with the management of multiple sclerosis patients, International grant reviewer: The National Health Laboratory Service Research Trust (NHLSRT) Grants, The Medical Research Council (MRC), South Africa, 20 May - 17 June 2009.

Tam Y.S.I., Epidermal Growth Factor Receptor (EGFR) Mutations and Phosphorylation Pattern in Non-Small Cell Lung Ccancer (NSCLC), 2008.

Yam J.W.P., UK-HK Frontiers of Science Symposium, Organised in Hong Kong by the Royal Society, with the support of the Croucher Foundation and the Department of Biochemistry, Hong Kong University of Science and Technology. 2009.