Room 035, 6/F, Block T, Queen Mary Hospital

A Seminar 

by

Dr ZHANG Qingyang
Post-doctoral Fellow 
Department of Pathology 
School of Clinical Medicine 
The University of Hong Kong 

and
 
The Translation Value of BQ323636.1, 
a splice variant of NCOR2, in the Management of ER-positive Breast Cancer 

by 

Dr TSOI Ho, Frankie 
Research Assistant Professor 
Department of Pathology 
School of Clinical Medicine 
The University of Hong Kong 

Room 035, 6/F, Block T, Queen Mary Hospital

A Seminar

Metabolic reprogramming of pentose phosphate pathway mediated by
small extracellular vesicles facilitates tumor metastasis and drug resistance in hepatocellular carcinoma

by

Dr ZHANG Xiaoxin, Post-doctoral Fellow
Department of Pathology
School of Clinical Medicine
The University of Hong Kong

and

Optimization of the library to enhance DIA proteomics for the identification of HCC biomarkers

by

Professor MA Hoi Tang, Ken, Assistant Professor
Department of Pathology
School of Clinical Medicine
The University of Hong Kong

All are welcome

Concord Room, Level 8, Renaissance Harbour View Hotel Hong Kong

Click here for details

Room 035, 6/F, Block T, Queen Mary Hospital

A Seminar

Exploring the heterogeneity of hypoxia response and investigating the role of synonymous mutations
in hepatocellular carcinoma: a multi-omics analysis

by

Mr Wang Gengchao
PhD student
Department of Pathology
School of Clinical Medicine
The University of Hong Kong

and

Clathrin light chain A-enriched small extracellular vesicles remodel microvascular niche
to induce hepatocellular carcinoma metastasis

by

Dr Xu Yi
Post-doctoral Fellow
Department of Pathology
School of Clinical Medicine
The University of Hong Kong

All are welcome

JW Marriott Hotel Hong Kong, 88 Queensway, Admiralty, Hong Kong & Via Zoom

For details: 

https://skllr.med.hku.hk/en/News-And-Events/Events

Room 035, 6/F, Block T, Queen Mary Hospital

A Seminar

Deciphering the impacts of collagen type I and interleukin-6 in diffuse-type gastric cancer progression
using CDH1-deficient human gastric organoid models

by

Miss Choy Hiu Ching

MPhil student
Department of Pathology
School of Clinical Medicine
The University of Hong Kong

and

Modelling diffuse-type gastric cancer in human organoids by CRISPR/Cas9

by

Dr Choi Jeeeun
Post-doctoral Fellow
Department of Pathology
School of Clinical Medicine
The University of Hong Kong

All are welcome

Lecture Theatre, 2/F, Block T, Queen Mary Hospital

A Seminar

Infection, Cell Plasticity and Upper GI Cancers

by

Professor Xin Lu

Ludwig Institute for Cancer Research
Nuffield Department of Medicine
University of Oxford, UK

Professor Xin Lu is the Director of the Ludwig Institute for Cancer Research and Professor of Cancer Biology at the University of Oxford, UK.  She is a leading cancer cell biologist with long-standing research interests in tumour suppression.  She was one of the first researchers to show that the tumour suppressor p53 responds to both oncogene activation and DNA damaging signals and her group was also among the first to demonstrate how to selectively activate p53 to kill cancer cells, through identification and characterization of the evolutionarily conserved ASPP family of proteins. Her laboratory has broad interests in the molecular mechanisms that control cellular plasticity, including how external signals - such as infection - are integrated into the nucleus to achieve target-selective transcription and cell fate determination. 

Professor Lu has been elected as a Fellow of the Royal Society 2020, the UK’s distinguished academy of science, for her contributions to cancer biology. Xin is also a Member of the Academy of Medical Sciences, a Member by election of the Academia Europaea, and a Member of the European Molecular Biology Organisation. Xin is Co-Director of the Cancer Research UK Oxford Centre, Cancer Theme Leader for the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre and Director of the Oxford Centre for Early Cancer Detection. She has a BSc from Sichuan University, MSc from Peking Union Medical College, Chinese Academy of Medical Sciences in China, PhD from University College London (UCL) and the former Imperial Cancer Research Fund, and postdoctoral training at Dundee University, UK. She was appointed as the Director of Ludwig Institute in London at UCL in 2004 and she established Ludwig Oxford as Director in 2007.

All are welcome

Room 035, 6/F, Block T, Queen Mary Hospital

A Seminar

Long-read sequencing uncovers alternative transcript isoforms essential for hypoxic adaptation in hepatocellular carcinoma

by

Miss WAN Ting Chi Rebecca

PhD student
Department of Pathology
School of Clinical Medicine
The University of Hong Kong

and

The Role of Small Extracellular Vesicle-derived Nicotinamide Phosphoribosyltransferase (NAMPT) in the Progression of Hepatocellular Carcinoma

by

Dr NG Tung Him Tony
Post-doctoral Fellow
Department of Pathology
School of Clinical Medicine
The University of Hong Kong

All are welcome

Room 035, 6/F, Block T, Queen Mary Hospital

A Seminar

Immunophenotyping of anti-PD-L1 treated hepatocellular carcinoma (HCC)

by

Miss SIT Fu Wan
MPhil student
Department of Pathology
School of Clinical Medicine
The University of Hong Kong

and

Targeting oncogenic m6A demethylase FTO suppresses tumorigenesis and potentiates immunotherapy efficacy in hepatocellular carcinoma

by

Dr CHEN Ao
Post-doctoral Fellow
Department of Pathology
School of Clinical Medicine
The University of Hong Kong

All are welcome

Room 035, 6/F, Block T, Queen Mary Hospital

A Seminar

Sensitive and Accurate Viral Integration Detection in HBV-associated Hepatocellular Carcinoma

by

Miss Lyu Xueying
PhD student
Department of Pathology
School of Clinical Medicine
The University of Hong Kong

Synopsis:

Hepatitis B virus (HBV) infection is one of the key etiological risk factors for HCC. Sensitive and accurate detection of HBV integration is crucial to the investigation of the molecular pathogenesis of HCC. We developed the software AVID for HBV integration detection with the enhanced algorithm. AVID outperformed other existing tools in terms of precision, F1 score, and recall in simulated datasets and experimentally validated datasets. Notably, regarding the landscape of HBV integration in HCC, we were able to sensitively and accurately identify recurrent HBV integration events related to TERT, KMT2B, and CCNE1.

and

Anti-Stanniocalcin 1 Antibody as a Potential Therapeutic Strategy for Liver Fibrosis and Hepatocellular Carcinoma

by

Mr Suen Long Hin
MPhil student
Department of Pathology
School of Clinical Medicine
The University of Hong Kong

Synopsis:

Liver fibrosis is part of the multi-step hepatocarcinogenesis process and persists after the development of hepatocellular carcinoma (HCC). Stanniocalcin 1 (STC1) is a serum biomarker in liver fibrosis and HCC, which is functionally involved in both diseases. In this study, the preclinical efficacy of anti-STC1 antibody in mitigating both metastatic potential of HCC cells and activation of hepatic stellate cells (HSCs) was evaluated. The functional role of anti-STC1 antibody in the interplay between HSCs and HCC cells was also studied. The downstream molecular mechanisms mediated by anti-STC1 antibody in the liver fibrosis cell line model was elucidated by proteomic profiling.

All are welcome

Room 035, 6/F, Block T, Queen Mary Hospital

A Seminar

STING agonist as novel and effective therapy in anti-PD-1 resistant liver cancers

by

Dr CHAN Yuen Ki
Post-doctoral Fellow
Department of Pathology
School of Clinical Medicine
The University of Hong Kong

and

RalA enhances metastasis in hepatocellular carcinoma via upregulating exosomal fibronectin

by

Dr TIAN Lu
Post-doctoral Fellow
Department of Pathology
School of Clinical Medicine
The University of Hong Kong

All are welcome

Island-Shangri-La Hotel, Hong Kong (Atrium, Level 39) & via Zoom

Click here for more information, and here for event photos

1:00PM-2:00PM, Thursday, 2 December 2021, Room 035, 6/F, Block T, Queen Mary Hospital

Research Postgraduate Seminar:

Targeting CHK2 to Reverse the Tamoxifen
Resistance by Reducing BQ323636.1 in Estrogen
Receptor Positive Breast Cancer
by
Mr Tsang Wai Chung, M. Phil Student

(Supervisor: Professor KHOO UI Soon)

Synopsis:

"BQ323636.1 (BQ) a splice variant of NCOR2, is associated with tamoxifen (TAM) resistance. TAM can cause DNA-damage, triggering the ATM-CHK2 DNA-damage response pathway. We hypothesized this might upregulate BQ-expression, causing TAM resistance. Targeting ATM can cause BQ downregulation, but results in cytotoxicity. Hence targeting CHK2, downstream of ATM, might be a better strategy. Using TAM resistant cell-line LCC2, we confirmed that CHK2-knockdown, or treating cells with CHK2 inhibitor, PV1019, could reduce BQ-expression and sensitize LCC2 to tamoxifen, both in vitro and in vivo. These findings suggest that targeting CHK2 could be a strategy for reducing TAM resistance in breast cancer."

All are welcome

A Seminar:

Single-cell RNA sequencing shows
the immunosuppressive landscape
and tumor heterogeneity of HBVassociated hepatocellular
carcinoma
by
Dr Ho Wai Hung Daniel
Assistant Professor
Department of Pathology

The University of Hong Kong
25 November 2021 (Thursday)
Time: 1:00 pm
Venue: Delivered via Zoom
Meeting ID: 996 5683 6618

MLT CPD code: 04211041
CME:1 point (HKCPath)

A Seminar:

Deconstruct a Novel Mutation Signature from Colon Cancer
by
Dr Siu Hoi Cheong Post-doctoral Fellow
Department of Pathology
The University of Hong Kong

Date:   28 October 2021 (Thursday)
Time:  1:00 pm (HKT)
Venue:  Delivered via Zoom
Meeting ID: 917 7273 2577
All are welcome
Registration

MLT CPD code: 04211031
CME:1 point (HKCPath)

Room 035, 6/F, Block T, Queen Mary Hospital

Research Postgraduate Seminar:

Dysregulation of Ral GTPase-Activating Protein Complex Activates RalA Signaling and Supports Metastasis of Hepatocellular Carcinoma through Intrinsic and Extracellular Vesicle-dependent Manners

by

Ms Tian Lu, PhD student

(Supervisor: Professor Ng Oi Lin Irene)

1:00PM-2:00PM, Thursday, 30 September 2021 Room 035, 6/F, Block T, Queen Mary Hospital

Room 035, 6/F, Block T, Queen Mary Hospital

Research Postgraduate Seminar:

The Role of Lumican in Hepatocellular Carcinoma
by

Miss Wong Cheuk Yan, MPhil student
(Supervisor: Dr Lo Cheuk Lam Regina)

Monopolar Spindle 1 (MPS1) Kinase Inhibitor Abrogates the Spindle Assembly Checkpoint and Leads to Insurmountable Genome Instability and Cell Death in Uterine Leiomyosarcoma
by
Mr Wong Ho Shing, MPhil student
(Supervisor: Dr Ip Pun Ching Philip)

1:00PM-2:00PM, Thursday, 26 Aug 2021 Room 035, 6/F, Block T, Queen Mary Hospital

Conducted via Zoom
Meeting ID:   975 1152 1794
Registration: https://hku.zoom.us/meeting/register/tJModuitrDotE9CFgLJeFk67xwOx5_77ORm-

Meeting ID: 975 1152 1794
MLT CPD code: 04211021

CME:1 point (HKCPath)

Room 035, 6/F, Block T, Queen Mary Hospital

Research Postgraduate Seminar:

Decoding the Function of Long Noncoding RNAs in Hepatocellular Carcinoma
by Miss Wong Lok Sze, PhD student
(Supervisor: Wong Chun Ming Jack)

The Role of IL-25 in the Pathogenesis of Sjögren's Syndrome
by Mr Deng Chong, PhD student
(Supervisor: Professor Lu Liwei)

1:00PM-2:00PM, Thursday, 29 July 2021 Room 035, 6/F, Block T, Queen Mary Hospital

Room 035, 6/F, Block T, Queen Mary Hospital

Research Postgraduate Seminar:

The Role of B Cells in the Development of Sjögren's Syndrome
by Mr Du Wenhan,
PhD student (Supervisor: Professor Lu Liwei)

Arsenic Trioxide-induced Autophagy and its Role in T-cell Acute Lymphoblastic Leukemia
by Miss Qiu Yinxia, MPhil student
(Supervisor: Dr Sin Chun Fung Albert )

1:00PM-2:00PM, Thursday, 15 July 2021 Room 035, 6/F, Block T, Queen Mary Hospital

G/F, Lecture Theatre 2, William MW Mong Block, 21 Sassoon Road, Pokfulam

Immunology- the Organ for All Seasons

More about Speaker information:

Professor Tak Wah MAK
Professor Leo Lit-Man POON
Dr Heidi Guang-Sheung LING
Dr Carmen Chak-Lui WONG

For in-person attendance, please register on or before 24 June 2021 (Thursday) via the link below

https://hkuems1.hku.hk/hkuems/ec_hdetail.aspx?ueid=75848

Please bring your registration record to the staff on-site for final confirmation.

For online Zoom attendance, please register via the link below:

https://hku.zoom.us/meeting/register/tJApceuvqDMsGNL4LPLR92ooFjII6ymV4T4V

For enquiries, please contact the Department of Pathology at tel:  2255 2664 / email: lklei@pathology.hku.hk

Date: June 5, 2021 (Saturday)
Time: 9:00 am to 5:00 pm
Format: Hybrid
Online – Zoom
Onsite – The Park Lane Hong Kong A Pullman Hotel (310 Gloucester Road, Causeway Bay)

Full detail : http://www.skllr.hku.hk/en/News-And-Events/Events

Free registration ( Click Here)

Venue: Conducted via Zoom (click here)
Meeting ID: 966 5602 4899

MLT CPD code: 04211011
CME:1 point (HKCPath)

Venue: Conducted via Zoom (click here)
Meeting ID: 997 5078 1537

Venue: Conducted via Zoom (click here)
Meeting ID: 953 7477 1429

Venue: Conducted via Zoom
Meeting ID: 920 8466 0074

Forum Detail
Symposium I: Liver
State-of-the-Art Lectures
Symposium II: Molecular and Genetics & Genomics
Symposium III: Artificial Intelligence and Computational Pathology

Click here for full detail

Venue: Conducted via Zoom
Meeting ID: 969 0009 4929

Venue: Conducted via Zoom
Meeting ID: 940 2328 0499

Venue: Conducted via Zoom

 Meeting ID: 978 8221 0800

Venue: Conducted via Zoom
Meeting ID: 941 8792 7373

Conducted by Zoom 

Click Here to join or by zoom 

Meeting ID:946 6507 3911

Application Deadline 1200(noon) 12 Aug 2020

18 July 2020(Saturday).

Due to COVID-19 situation, Symposium change to online with zoom

Lecture Theatre, 2/F, Block T, Queen Mary Hospital, 102 Pokulam Road, Hong Kong

Room N201 (New Wing), Hong Kong Convention & Exhibition Centre, Hong Kong

Venue:Room N201 (New Wing), Hong Kong Convention & Exhibition Centre, Hong Kong

The University Pathology Building (UPB) will be decommissioned in 2018 as part of the Queen Mary Hospital (QMH) redevelopment plan. Since its establishment, UPB has played important role in the undergraduate and postgraduate education of pathology in Hong Kong as well as contributing to breakthrough in research and advancement of clinical services. Besides lectures and practical classes for pathology teaching for medical students, postgraduate courses for medical and related professions are also held in UPB. UPB is also the venue for the annual College examinations. In recent years, educational workshop for the public, particularly high school students, are often conducted in UPB as activities to publicize the International Pathology Day.

To cherish fond memories of UPB and to celebrate its historical importance, the University of Hong Kong Departments of Microbiology and Pathology jointly organized a “Farewell to UPB” on October 21, 2017 (Sat).

Fare UPB even photos